weller roy o neurodegeneration the molecular pathology of dementia and movement disorders

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Weller Roy O. Neurodegeneration. The Molecular Pathology of Dementia and Movement Disorders

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

22369.82 рублей

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Crichton Robert Metal-Based Neurodegeneration. From Molecular Mechanisms to Therapeutic Strategies

Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

15284.87 рублей

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Coope Bernard ABC of Dementia

ABC of Dementia is a practical guide to help healthcare professionals develop knowledge, skills, confidence and an understanding of dementia, in order to support those with dementia to live well. It begins with the cognitive disabilities and underlying brain diseases that define dementia, before moving on to diagnostic assessment and early intervention for dementia. There is a focus on the experience of the person with dementia and their families, highlighting the journey from diagnosis to end of life, including the role of person-centred care, and the limited therapeutic options available. Separate chapters address dementia in acute hospital settings, primary care, and care for those with the most severe challenges, as well as the specific needs of younger people developing dementia. The ethical and legal context of dementia care is also outlined. From a multidisciplinary author team, ABC of Dementia is a valuable resource for general practitioners, family physicians and other health care professionals caring for patients with dementia and related disorders. It is also relevant for geriatricians, psychologists, specialist and practice nurses, and nursing home staff.

2803.87 рублей

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Scott Hooper L. Neurobiology of Motor Control. Fundamental Concepts and New Directions

A multi-disciplinary look at the current state of knowledge regarding motor control and movement—from molecular biology to robotics The last two decades have seen a dramatic increase in the number of sophisticated tools and methodologies for exploring motor control and movement. Multi-unit recordings, molecular neurogenetics, computer simulation, and new scientific approaches for studying how muscles and body anatomy transform motor neuron activity into movement have helped revolutionize the field. Neurobiology of Motor Control brings together contributions from an interdisciplinary group of experts to provide a review of the current state of knowledge about the initiation and execution of movement, as well as the latest methods and tools for investigating them. The book ranges from the findings of basic scientists studying model organisms such as mollusks and Drosophila, to biomedical researchers investigating vertebrate motor production to neuroengineers working to develop robotic and smart prostheses technologies. Following foundational chapters on current molecular biological techniques, neuronal ensemble recording, and computer simulation, it explores a broad range of related topics, including the evolution of motor systems, directed targeted movements, plasticity and learning, and robotics. Explores motor control and movement in a wide variety of organisms, from simple invertebrates to human beings Offers concise summaries of motor control systems across a variety of animals and movement types Explores an array of tools and methodologies, including electrophysiological techniques, neurogenic and molecular techniques, large ensemble recordings, and computational methods Considers unresolved questions and how current scientific advances may be used to solve them going forward Written specifically to encourage interdisciplinary understanding and collaboration, and offering the most wide-ranging, timely, and comprehensive look at the science of motor control and movement currently available, Neurobiology of Motor Control is a must-read for all who study movement production and the neurobiological basis of movement—from molecular biologists to roboticists.

14444.61 рублей

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Albanese Alberto Hyperkinetic Movement Disorders. Differential Diagnosis and Treatment

Hyperkinetic movement disorders comprise a range of diseases characterized by unwanted and uncontrollable, or poorly controllable, involuntary movements. The phenomenology of these disorders is quite variable encompassing chorea, tremor, dystonia, myoclonus, tics, other dyskinesias, jerks and shakes. Discerning the underlying condition can be very difficult given the range and variability of symptoms. But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders. The stellar international cast of authors distils the evidence so you can apply it into your practice. The judicious use of diagnostic criteria algorithms rating scales management guidelines Provides a robust framework for clear patient management. Throughout the text, QR codes* provide smartphone access to case-study videos of hyperkinetic symptoms. Purchase includes an enhanced Wiley Desktop Edition.* This is an interactive digital version featuring: all text and images in fully searchable form integrated videos of presentations View a sample video: www.wiley.com/go/albanese highlighting and note taking facilities book marking linking to additional references Hyperkinetic Movement Disorders provides you with the essential visual and practical tools you need to effectively diagnose and treat your patients. *Full instructions for using QR codes and for downloading your digital Wiley DeskTop Edition are inside the book.

12549.1 рублей

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Gary Kanel C. Pathology of Liver Diseases

Pathology of Liver Diseases is a rapid reference consultation tool that uses both book and online material to present a whole range of liver disorders. The book emphasizes not only the pathology seen in biopsy and surgical material, but also the most pertinent clinical and laboratory findings including epidemiology, etiologic and pathophysiologic concepts, and the differential diagnoses. Key references appear at the end of each chapter. The book is also accompanied by a companion website: www.wiley.com/go/kanel/liverpathology It contains the following online material: A complete Reference List. A Library that contains over 860 images of the various liver diseases, which adds to over 540 images that are in the book itself Additional Tables that address in detail the grading and staging of various liver diseases such as viral hepatitis and fatty liver diseases. 140 Case Examples, which include over 420 images that demonstrate the various ways many of these disease entities clinically present. A PowerPoint presentation entitled «Liver Transplantation – Surgical Procedure», which includes photographs from the operating table of the step-by-step process in liver transplantation. Pathology of Liver Diseases provides gastroenterologists and pathologists with a multi-media, well-illustrated, and concise guide to the pathology and clinical diagnoses of liver disorders.

18059.87 рублей

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Simon Atkins Dementia For Dummies - UK

Your hands-on guide to dealing with dementia within the UK healthcare system If a loved one has recently been diagnosed with dementia, Dementia For Dummies, UK Edition provides trusted, no-nonsense guidance on what this may mean for you and your family. You'll get an understanding of the symptoms of dementia, make sense of the stages of the illness and grasp the differences between the various types of dementia, including Alzheimer's disease and vascular dementia. Dementia is an increasingly common condition that can have a significant impact on family life. Each person diagnosed is unique, and your loved one's symptoms can range from loss of memory to mood changes to communication problems and beyond. This sensitive, authoritative guide walks you through the different scenarios you may encounter as a family member or carer and explains step-by-step how you can keep your loved one as safe and as comfortable as possible—no matter how severe their symptoms are. Gives you the straight facts on dementia Covers the symptoms, causes and risk factors of dementia Helps identify and address the fears as you face a diagnosis Provides carers and family members with the information needed to help manage the illness If you're looking for support as you adjust to caring for a loved one with dementia, Dementia For Dummies helps make it easier.

1415.48 рублей

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Andres Kanner Depression in Neurologic Disorders. Diagnosis and Management

Depression in Neurologic Disorders Diagnosis and Management Edited by Andres M. Kanner, MD, Professor of Neurological Sciences and Psychiatry, Rush Medical College at Rush University, Chicago, IL, USA. Why should neurologists care about depression? It is one of the most frequent psychiatric comorbid conditions of neurologic disorders. Not only does it have a negative impact on the quality of patients, but it is also associated with a worse course of the neurologic disease. Yet, more often than not, neurologists have not been trained to recognize clinical depression in their patients. How should neurologists learn to care for depression? By reading Depression in Neurologic Disorders, the caring neurologist will gain a practical overview of: clinical manifestations of depression in the major neurologic disorders how to use screening instruments in clinical practice the identification of patients with an increased suicidal risk basic principles of the management of depressive disorders by the non-psychiatrist The major neurologic disorders covered in Depression in Neurologic Disorders include: Migraine Stroke Epilepsy Parkinson’s Disease Multiple Sclerosis Huntington’s Disease Dementia Traumatic Brain Injury The practical approach is enhanced with the use of case studies and ‘take-home pearls’ throughout. Depression is a common disorder that all neurologists face in their daily clinical practice. Depression in Neurologic Disorders provides the fundamentals of caring for patients who are suffering beyond their diagnosed neurologic disorder. Titles of Related Interest Adult Epilepsy Gregory Cascino and Joseph Sirven (eds); ISBN 978-0-470-74122-1 Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment Alberto Albanese and Joseph Jankovic (eds); 978-0-470-74122-1 Multiple Sclerosis: Diagnosis and Therapy Howard Weiner and James Stankiewicz; 978-0-470-65463-7

7306.46 рублей

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Michael Brainin European Handbook of Neurological Management

Evidence-based, peer reviewed, best practice management guidelines for neurologists Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the European Journal of Neurology for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with 'Recommendations' based on strong evidence and 'Good Practice Points' where only weaker evidence is available. The Guidelines in this volume include, amongst others: Neurostimulation therapy for neuropathic pain Molecular diagnosis for a range of neurological conditions Intravenous immunoglobulin in the treatment of neurological diseases Sleep disorders in neurodegenerative disorders and stroke Management of low-grade gliomas Treatment of miscellaneous idiopathic headache disorders The European Handbook of Neurological Management provides a thoroughly rounded and grounded approach to best-practice neurological management using evidence-based principles. Titles of related interest Cerebrovascular Ultrasound in Stroke Prevention, 2e Alexandrov (ed); ISBN 9781405195768 Parkinsons's Disease: Non-Motor and Non-Dopaminergic Features Olanow, Stocchi and Lang (eds); ISBN 9781405191852 Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment Albanese and Jankovic (eds); ISBN 9781444333527

16541.8 рублей

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Sally Blythe Goddard Neuromotor Immaturity in Children and Adults. The INPP Screening Test for Clinicians and Health Practitioners

Available to healthcare professionals for the first time, this book contains proven screening tests to measure neuromotor immaturity in children and adults in order to provide a basis for referral and help. Allows practitioners to screen for disorders of movement that can negatively affect educational performance and emotional function in children and adolescents Assesses instances where disorders of movement in adults are affecting thoughts and behavior, as in panic disorder Provides a novel approach for health care professionals observing aberrant reflexes in the absence of more serious pathology Includes reproducible scoring and observation sheets for practice and serves as the perfect complement to Assessing Neuromotor Readiness for Learning

7003.67 рублей

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Robert Ord A. Salivary Gland Pathology. Diagnosis and Management

Salivary Gland Pathology: Diagnosis and Management, Second Edition, updates the landmark text in this important discipline within oral and maxillofacial surgery, otolaryngology/head and neck surgery, and general surgery. Written by well-established clinicians, educators, and researchers in oral and maxillofacial surgery, this book brings together information on the etiology, diagnosis, and treatment of all types of salivary gland pathology. Clear and comprehensive, Salivary Gland Pathology: Diagnosis and Management offers complete explanation of all points, supported by a wealth of clinical and surgical illustrations to allow the reader to gain insight into every facet of each pathologic entity and its diagnosis and treatment. Salivary Gland Pathology: Diagnosis and Management offers comprehensive coverage of all aspects of this topic. Beginning with the embryology, anatomy and physiology of the salivary glands, the first section of the book discusses radiographic imaging, infections, cystic conditions, sialoadenitis and sialolithiasis, and systemic diseases. The second section of the book is devoted to the classification of salivary gland tumors and devotes individual chapters to the discussion of each type. Additions for this section of the second edition include molecular biology of salivary gland neoplasia, radiation therapy, and chemotherapy and targeted therapy for salivary gland malignancies. The book closes with a discussion of pediatric salivary gland pathology, traumatic injuries of the salivary glands and miscellaneous pathologic processes of the salivary glands and ducts, including a section on saliva as a diagnostic fluid. The book is intended for a very diverse audience, including academic oral and maxillofacial surgeons, otolaryngologists / head and neck surgeons, general surgeons, as well as residents in these disciplines. Private practitioners will want to place this publication on the bookshelves of their offices so as to consult the textbook when evaluating a patient with salivary gland pathology.

14446.66 рублей

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Paul Higgs Ageing, Dementia and the Social Mind

A groundbreaking exploration of the sociology of dementia – with contributions from distinguished international scholars and practitioners. Organised around the four themes of personhood, care, social representations and social differentiation Provides a critical look at dementia and demonstrates how sociology and other disciplines can help us understand its social context as well as the challenges it poses Contributing authors explore the social terrain, responding in part, to Paul Higgs’ and Chris Gilleard’s highly influential work on ageing Breaks new ground in giving specific attention to the social and cultural dimensions of responses to dementia

2524.86 рублей

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Kevin Mitchell J. The Genetics of Neurodevelopmental Disorders

Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.

10832.08 рублей

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Caroline Belkoura Racine Non-Alzheimer's and Atypical Dementia

Dementia is the most common type of neurodegenerative disorder. Non-Alzheimer's and Atypical Dementia concentrates on each form of dementia individually, considering symptoms, diagnosis and treatment Focuses on non-Atypical Dementia Multidisciplinary approach to diagnosis and management Allows development of management and care plan strategies Practical approach including case studies Written by a world-renowned editorial team

9026.16 рублей

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Tahira Farooqui Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome – abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension – to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.

15382.86 рублей

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B. A. Kazakovtsev Mental Disorders in Epilepsy

The monograph shows the opportunity to study the pathogenesis of mental disorders in epilepsy based on the characteristics of its fl ow using clinical methods, structural dynamic, epidemiological and statistical analysis. Structural and dynamic analysis of the major clinical manifestations of the disease (features of personality changes, paroxysmal disorders, psychotic symptoms, dementia) held in accordance with the main patterns of development of the disease, its types and stages. On the basis of the multi-axial classifi cation of epilepsy was developed a model that allows in a retrospective analysis of an-amnestic data and clinical assessment to establish clinical and social criteria for prognosis prediction.

400 рублей

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Kazakovtsev B. A. Mental Disorders in Epilepsy

The monograph shows the opportunity to study the pathogenesis of mental disorders in epilepsy based on the characteristics of its flow using clinical methods, structural dynamic, epidemiological and statistical analysis. Structural and dynamic analysis of the major clinical manifestations of the disease (features of personality changes, paroxysmal disorders, psychotic symptoms, dementia) held in accordance with the main patterns of development of the disease, its types and stages. On the basis of the multi-axial classification of epilepsy was developed a model that allows in a retrospective analysis of anamnestic data and clinical assessment to establish clinical and social criteria for prognosis prediction

1199 рублей

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W. Craighead Edward Psychopathology. History, Diagnosis, and Empirical Foundations

Fully revised to incorporate DSM-5 criteria and informed by the most current research in its discussions of diagnosis and treatment Now in a second edition, Psychopathology: History, Diagnosis, and Empirical Foundations thoroughly explores psychopathology with contributions from leading scholars in psycho-pathology. The Second Edition offers an overview of various topics in the context of major changes included in the DSM-5. With new chapters on contextual factors affecting diagnoses and non-alcohol substance abuse, Psychopathology, Second Edition covers the history, theory, and assessment of anxiety disorders, posttraumatic stress disorder, mood disorders, schizophrenia, the psychotic spectrum disorders, eating disorders, borderline personality disorder, alcohol use disorders, psychopathy, sexual dysfunction, and sleep disorders. In addition, each chapter of the Second Edition contains: A description of the disorder, including brief history, case example, and epidemiological findings Empirical foundations of each disorder, including findings regarding neurobiological, behavioral, cognitive, and emotional factors Assessment of each disorder, including interviews, self-reports, neurobiological assessment, and clinical rating scales Brief description and evaluation of the current interventions for each disorder Summary and future directions Practical and thorough, this text is an essential reference for all mental health professionals and a solid introduction for students in psychopathology courses.

7223.67 рублей

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A multi-disciplinary look at the current state of knowledge regarding motor control and movement—from molecular biology to robotics The last two decades have seen a dramatic increase in the number of sophisticated tools and methodologies for exploring motor control and movement. Multi-unit recordings, molecular neurogenetics, computer simulation, and new scientific approaches for studying how muscles and body anatomy transform motor neuron activity into movement have helped revolutionize the field. Neurobiology of Motor Control brings together contributions from an interdisciplinary group of experts to provide a review of the current state of knowledge about the initiation and execution of movement, as well as the latest methods and tools for investigating them. The book ranges from the findings of basic scientists studying model organisms such as mollusks and Drosophila, to biomedical researchers investigating vertebrate motor production to neuroengineers working to develop robotic and smart prostheses technologies. Following foundational chapters on current molecular biological techniques, neuronal ensemble recording, and computer simulation, it explores a broad range of related topics, including the evolution of motor systems, directed targeted movements, plasticity and learning, and robotics. Explores motor control and movement in a wide variety of organisms, from simple invertebrates to human beings Offers concise summaries of motor control systems across a variety of animals and movement types Explores an array of tools and methodologies, including electrophysiological techniques, neurogenic and molecular techniques, large ensemble recordings, and computational methods Considers unresolved questions and how current scientific advances may be used to solve them going forward Written specifically to encourage interdisciplinary understanding and collaboration, and offering the most wide-ranging, timely, and comprehensive look at the science of motor control and movement currently available, Neurobiology of Motor Control is a must-read for all who study movement production and the neurobiological basis of movement—from molecular biologists to roboticists.

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