wafaa ghoneim shousha moataza hassan omran and basma el sayed fotouh salieh lmp 7 gene and response to ifn therapy in hcv infected patients

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Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors

Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.

11618.58 рублей

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Róza El-Hassan. In Between: Drawings and Objects

Roza El-Hassan (born 1966) is one of Hungary's most prominent contemporary artists, and her drawings, sculptures, installations, actions and videos have been exhibited...

1900 рублей

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Jenny Broersen Mindfulness and Schema Therapy. A Practical Guide

Mindfulness and Schema Therapy presents an eight-session + two follow up sessions protocol for schema mindfulness for therapists and their patients. Represents the first book to integrate the theory of schema therapy with the techniques of mindfulness Enhances schema therapy with techniques drawn from mindfulness-based cognitive therapy (MBCT) – a unique integration of two of the most popular treatment approaches in clinical psychology today. Merges two of the hottest topics in contemporary clinical psychology and psychotherapy Offers a practical guide for training and practice, with detailed coverage of theory followed by dedicated sections for therapists and patients Features a variety of exercises enabling readers to immediately implement the protocol Written by authors with expertise and experience in both schema therapy and mindfulness Includes a Foreword by Mark Williams, renowned for his contribution to the development of MBCT

8544.63 рублей

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Hosseini K. The Kite Runner



Amir and Hassan grow up together in Kabul. Amir in the beautiful house his father built, filled with marble, gold, tapestries and mosaics; Hassan in the modest mud hut in the servants' quarters.

The two are inseparable, and when twelve-year-old Amir is desperate to win the local kite-fighting tournament, his loyal friend promises to help him. But neither boy can predict what will happen to Hassan that afternoon - as the kites soar over the city - and how it will change their lives forever.

607 рублей

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Mohamad Mohty Clinical Guide to Transplantation in Lymphoma

The first book on clinical guide to transplantation in lymphoma to present cutting edge knowledge on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies Discusses organizational aspects of transplant patients and managing a transplant program Appendices provide practical quick-reference information on follow-up after autologous and allogenic stem cell transplantation in lymphoma

11468.48 рублей

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Mario Lacouture E. Dermatologic Principles and Practice in Oncology. Conditions of the Skin, Hair, and Nails in Cancer Patients

The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.

13943.19 рублей

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Montgomery Stuart A. Treatment-Resistant Depression

Successful management of patients with treatment-resistant depression is going to require a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest scientific research and its applications in clinical practice. A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes. The opening chapter reviews definitions and predictors of originating from different fields and discusses their usefulness in clinical practice and clinical research. The next chapter proposes a new definition, adapting terminology from medicine. Biological classification requires identification of genetic risk factors: with gene variants accounting for 50% of the variance in the clinical outcomes of antidepressant treatments this is clearly a fruitful area of research. Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, predicts that genetic prediction of TRD could became a widespread clinical reality within a few years. Most patients with TRD will be treated pharmacologically and three chapters review the latest evidence for pharmacological best practice, including switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium. There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy. The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy. The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, revealing that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy. It proposes indications for psychotherapy in TRD and summarizes general therapeutic principles.

4134.3 рублей

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Maully Shah Cardiac Pacing and Defibrillation in Pediatric and Congenital Heart Disease

With a growing population of young patients with congenital heart disease reaching adulthood, this unique new book offers an in-depth guide to managing the challenges and issues related to device therapy in this patient group. The only book resource dedicated to pacing, cardiac resynchronization therapy and ICD therapy for the pediatric and congenital heart disease patient Contains practical advice for pacemaker and ICD implantation, programming, trouble-shooting, managing complications and follow up Up-to-date with the latest in device technology Contains multiple graphics, device electrogram tracings, and radiographic images for clarity Includes video clips and over 150 multiple choice questions with extended answers on companion website, ideal for self test An invaluable resource for both the specialist pediatric cardiologist and the general cardiologist responsible for children with heart disease and pacing devices

14921.62 рублей

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John Dickenson Molecular Pharmacology. From DNA to Drug Discovery

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular

12368.4 рублей

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Charles Schaefer E. Handbook of Play Therapy

A complete, comprehensive play therapy resource for mental health professionals Handbook of Play Therapy is the one-stop resource for play therapists with coverage of all major aspects written by experts in the field. This edition consolidates the coverage of both previous volumes into one book, updated to reflect the newest findings and practices of the field. Useful for new and experienced practitioners alike, this guide provides a comprehensive introduction and overview of play therapy including, theory and technique, special populations, nontraditional settings, professional and contemporary issues. Edited by the founders of the field, each chapter is written by well-known and respected academics and practitioners in each topic area and includes research, assessment, strategies, and clinical application. This guide covers all areas required for credentialing from the Association for Play Therapy, making it uniquely qualified as the one resource for certification preparation. Learn the core theories and techniques of play therapy Apply play therapy to special populations and in nontraditional settings Understand the history and emerging issues in the field Explore the research and evidence base, clinical applications, and more Psychologists, counselors, marriage and family therapists, social workers, and psychiatric nurses regularly utilize play therapy techniques to facilitate more productive sessions and promote better outcomes for patients. Handbook of Play Therapy provides the deep, practical understanding needed to incorporate these techniques into practice.

5624.33 рублей

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Li Yi Plant Gene Containment

Gene Containment provides a comprehensive look at genetically modified organisms and the strategies and implementation of key methods to gene containment. The book is divided into 5 parts: An Introduction that discusses the need for biotechnology and GMOs, Section 1 looks at the need for gene containment, Part II discusses varying strategies for gene containment, section III explores the assessment of gene containment approaches, and section IV covers the steps involved in implementing gene containment. Gene Containment will provide a thorough and up to date look at gene containment research and the needs for implementing new strategies in this arena.

12640.45 рублей

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Foster Alethea V.M. Managing the Diabetic Foot

Foot problems in diabetic patients are some of the most challenging complications to treat, due to an often quite late presentation of symptoms from the patient. Therefore visual recognition of presenting clinical signs is absolutely key for a successful diagnosis and subsequently, the right management programme. The 3rd edition of Managing the Diabetic Foot once again provides a practical, handy and accessible pocket guide to the clinical management of patients with severe feet problems associated with diabetes, such as ulcers, infections and necrosis. By focusing on the need for a speedy response to the clinical signs, it will enable doctors make rapid, effective management decisions in order to help prevent deterioration and avoid the need for evental foot amputation. Each chapter focuses specifically on the different stages of foot disease and the clinical management required at that particular stage, ie, the normal foot; high-risk foot, ulcerated foot, infected foot, necrotic foot and unsalvageable foot. Full colour throughout, it will feature over 150 clinical photos, numerous hints and tips to aid rapid-reference, as well as the latest national and international guidelines on diabetic foot management. Managing the Diabetic Foot, 3E, is the ideal go-to clinical tool for all diabetes professionals, specialist diabetes nurses and podiatrists managing patients with diabetic foot problems.

5283.78 рублей

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Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set

Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

41240.57 рублей

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Gitta Jacob Breaking Negative Thinking Patterns. A Schema Therapy Self-Help and Support Book

Breaking Negative Thinking Patterns is the first schema-mode focused resource guide aimed at schema therapy patients and self-help readers seeking to understand and overcome negative patterns of thinking and behaviour. Represents the first resource for general readers on the mode approach to schema therapy Features a wealth of case studies that serve to clarify schemas and modes and illustrate techniques for overcoming dysfunctional modes and behavior patterns Offers a series of exercises that readers can immediately apply to real-world challenges and emotional problems as well as the complex difficulties typically tackled with schema therapy Includes original illustrations that demonstrate the modes and approaches in action, along with 20 self-help mode materials which are also available online Written by authors closely associated with the development of schema therapy and the schema mode approach

6969.59 рублей

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Trisha Greenhalgh User Involvement in Health Care

How can the needs and perspective of patients be incorporated in the design and redesign of health services? Health organizations are focusing more and more on patients – and requiring their employees to practise patient focused care. The Modernisation Initiative described in this book explores in three health service areas (kidney, stroke and sexual health services) how patients' and carers' involvement may inform and shape quality improvement work This book guides you through the issues and challenges that teams seeking to involve users in changing health services are likely to face. It offers a wealth of practical knowledge about involving users. Those undertaking similar programmes, whether in primary care or hospital based, will find ideas and examples in this book to inspire and guide them.

4570.75 рублей

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Rosemary Crouch Occupational Therapy in Psychiatry and Mental Health

Comprehensive and informative, the extensively revised fifth edition of Occupational Therapy in Psychiatry and Mental Health is an accessible overview of occupational therapy in psychiatry, providing key information on a range of international models of occupational therapy as well as their practical applications. The fifth edition includes: • Case studies throughout to illustrate application of theory to practice • Coverage of key concepts and issues in occupational therapy • New material on emerging areas of practice • Comprehensive information on assessment and treatment for children, adolescents and adults, covering key mental health conditions Occupational Therapy in Psychiatry and Mental Health is an ideal resource for students in occupational therapy, newly qualified and experienced practitioners, and other allied health professionals seeking an up-to-date, globally relevant resource on psychiatry and mental health care.

4649 рублей

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David Wesorick H. Hospitalists' Guide to the Care of Older Patients

The first book designed specifically for hospitalists and other hospital-based staff who need concise, evidence-based guidance on the vital topic of caring for older hospitalized patients Hospitalists' Guide to the Care of Older Patients is an up-to-date, practical reference in geriatric medicine for hospitalists, as well as other physicians and nurses working in the hospital setting. The book uses numerous tables, figures, and images to highlight the areas of geriatric medicine that are most relevant to hospitalists. Written by nationally recognized experts, chapters broadly follow the course of hospitalization, from admission through daily care and active management of the transition to post-hospital settings, providing practical, evidence-based guidance at each point. Contents include: A systematic approach to the care of older patients, emphasizing clinical skills and daily activities that can be implemented in today's hospital environment Techniques for effective communication with patients and their caregivers Tools and «pearls» for quickly and accurately assessing the whole patient, including risk for in-hospital complications, function, decision-making capacity, and home support Best practices for prevention and management of the complications of hospitalization, including delirium, falls, pressure ulcers, and hip fractures Specific recommendations in areas with wide practice variation, such as psychopharmacology and nutrition in older hospitalized patients Practical guidance on complex issues, such as establishing goals of care, managing patients who lack decision-making capacity, and managing the discharge transition Methods to improve the daily work and communication of the whole hospital team, including physicians, nurses, and other healthcare providers As the population ages, hospitalists are caring for an increasing number of older patients. This book helps hospitalists expand their knowledge, incorporate key clinical skills into daily practice, build more efficient patient care teams, and teach more effectively in today's fast-paced, complex hospital environment.

7195.1 рублей

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Okechukwu Ekenna Cases in Clinical Infectious Disease Practice

In the era of cost cutting and lack of adequate health insurance for many patients, clinical skills and time spent with patients are not adequately compensated. Yet, these dwindling and underpaid skills – good history taking, observation of and listening to patients, and physical examination of patients – remain very essential to making and reaching a complete and accurate diagnosis. Expensive laboratory and imaging diagnostics while very relevant, should not replace these age-old skills that have served to enhance and maintain the doctor-patient relationship and human connection, a connection that is often necessary for healing. Cases in Clinical Infectious Disease Practice uses case studies to illustrate how the infectious disease clinician processes and integrates data to arrive at a diagnosis. This type of hands-on approach, invaluable in training programs, is utilized to take the reader through initial patient encounter, through the history and physical examination, to simple laboratory findings and stains, to a final diagnosis, in a way that is easily accessible to clinicians, students, and laboratory personnel working with clinical specimens. Appeals to practitioners of all levels, with focus on patients with common problems or complications of common infections without heavy technical language Emphasizes basic clinical skills including history taking, observation, epidemiology, and physical exam, as well as simple laboratory tests, explaining how they lead to a reasonable diagnosis Presents cases seen first-hand within the community setting, reflective of cases or situations a resident or student is likely to encounter in the real world after training Cases in Clinical Infectious Disease Practice is an essential resource for clinicians, graduate and medical school students, and others conducting medical and clinical microbiology or infectious disease research on real patients.

11243.68 рублей

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