viji m o and parvatham r in vivo and in vitro studies on withania somnifera

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Dennis Smith A. Metabolite Safety in Drug Development

A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to toxicity tests, and drug-drug interactions • Includes perspectives from authors with firsthand involvement in industry and the study of drug metabolites, including viewpoints that have influenced regulatory guidelines

14622.12 рублей

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Souzan Yanni B. Translational ADMET for Drug Therapy. Principles, Methods, and Pharmaceutical Applications

Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval

10123.22 рублей

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Urban Laszlo Predictive ADMET. Integrated Approaches in Drug Discovery and Development

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.

11877.96 рублей

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Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations

Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

11247.23 рублей

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West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.

9885.53 рублей

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Roger Narayan Advances in Bioceramics and Porous Ceramics IV

This book is a collection of papers from The American Ceramic Society's 35th International Conference on Advanced Ceramics and Composites, held in Daytona Beach, Florida, January 23-28, 2011. This issue includes papers presented in the Next Generation Bioceramics and Porous Ceramics Symposia on topics such as Advanced Processing of Bioceramics; In Vitro and In Vivo Characterization of Bioceramics; Medical and Dental Applications of Bioceramics; Porous Bioceramics; Structure and Properties of Porous Ceramics; and Processing Methods of Porous Ceramics.

6744.78 рублей

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Robin A. de Graaf In Vivo NMR Spectroscopy. Principles and Techniques

Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.

9579 рублей

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Park Kinam Oral Controlled Release Formulation Design and Drug Delivery. Theory to Practice

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

10192.06 рублей

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Yuliang Zhao Toxicology of Nanomaterials

This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.

14247.21 рублей

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Nicolas Bordenave Functional Foods and Beverages. In vitro Assessment of Nutritional, Sensory, and Safety Properties

A much-needed guide to in vitro food functionality evaluation principles, processes, and state-of-the-art modeling There are more than a few books devoted to the assessment of food functionality but, until now, there were no comprehensive guides focusing on the increasingly important subject of in vitro food evaluation. With contributions from the world’s foremost experts in the field, this book brings readers up to speed on the state-of-the-art in in vitro modeling, from its physiological bases to its conception, current uses, and future developments. Food functionality is a broad concept encompassing nutritional and health functionality, food safety and toxicology, as well as a broad range of visual and organoleptic properties of food. In vitro techniques bridge the gap between standard analytical techniques, including chemical and biochemical approaches and in vivo human testing, which remains the ultimate translational goal for evaluation of the functionality of food. Although it is a well- established field, in vitro food testing continues to evolve toward ever more accurate predictions of in vivo properties and outcomes. Both ethical and highly economical, these approaches allow for detailed mechanistic insights into food functionalities and, therefore, a better understanding of the interactions of food and human physiology. Reviews the core concepts of food functionality and functionality evaluation methodologies Provides an overview of the physiology of the gastrointestinal tract, including host-microbial interactions within it Delves into the physiology of sensory perception of food, taste and texture as they relate to in vitro modeling Explores the challenges of linking in vitro analysis of taste, aroma and flavor to their actual perception Addresses in vitro models of the digestion and absorption of macronutrients, micronutrients, and phytonutrients Describes in vitro evaluations of toxicants, allergens and other specific food hazards Functional Foods and Beverages is an indispensable working resource for food scientists as well as researchers working in government facilities dedicated to tracking food safety.

12768.81 рублей

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Jamie Davies Replacing Animal Models. A Practical Guide to Creating and Using Culture-based Biomimetic Alternatives

Over the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments. The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiments, the book covers a range of methods and examples emphasising the design considerations that went into each system. The chapters also include 'case studies' that illustrate the ways in which culture models can be used to answer a range of important biological questions of direct relevance to human development, physiology, disease and healing. The thesis of this book is not that all animal experimentation can be replaced, now or in the near future, by equally effective or superior alternatives. Rather, the premise is that there is substantial opportunity, here and now, to do some common types of experiment better in vitro than in vivo, and that doing so will result in both scientific and ethical gains.

2139.84 рублей

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Meghan Manfra McGlinn The Wiley Handbook of Social Studies Research

The Wiley Handbook of Social Studies Research is a wide-ranging resource on the current state of social studies education. This timely work not only reflects on the many recent developments in the field, but also explores emerging trends. This is the first major reference work on social studies education and research in a decade An in-depth look at the current state of social studies education and emerging trends Three sections cover: foundations of social studies research, theoretical and methodological frameworks guiding social studies research, and current trends and research related to teaching and learning social studies A state-of-the-art guide for both graduate students and established researchers Guided by an advisory board of well-respected scholars in social studies education research

14622.12 рублей

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Davies Philip R. Scanning Tunneling Microscopy in Surface Science

Here, top international authors in the field of STM and surface science present first-class contributions on this hot topic, bringing the reader up to date with the latest developments in this rapidly advancing field. The focus is on the nanoscale, particularly in relation to catalysis, involving developments in our understanding of the nature of the surfaces of oxides and nanoparticulate materials, as well as adsorption, and includes in-situ studies of catalysis on such model materials. Of high interest to practitioners of surface science, nanoscience, STM and catalysis.

15399.2 рублей

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Tenenbaum Gershon Case Studies in Applied Psychophysiology. Neurofeedback and Biofeedback Treatments for Advances in Human Performance

A thorough, readable primer for the practitioner and student, detailing case studies on the art and science of biofeedback and neurofeedback in practice. Includes case-study examples focusing directly on improving human performance in non-clinical populations utilizing biofeedback and neurofeedback techniques Links theory and practice for scholars and practitioners in the field Acknowledges both the art and science of utilizing these tools for performance-related gains in sports and artistic fields, presenting unique case studies detailing the variety of procedures used Offers comprehensive coverage of key topics and procedures in an emerging field

7046.31 рублей

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Donald Nonini M. A Companion to Urban Anthropology

A Companion to Urban Anthropology presents a collection of original essays from international scholars on key issues in urban anthropology and broader cross-disciplinary urban studies. Features newly commissioned essays from 35 leading international scholars in urban and global studies Includes essays in classic areas of concern to urban anthropologists such as built structures and urban planning, community, security, markets, and race Covers emergent areas in the field including: 21st-century cities borders, citizenship, sustainability, and urban sexualities

15067.45 рублей

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Per Runeson Case Study Research in Software Engineering. Guidelines and Examples

Based on their own experiences of in-depth case studies of software projects in international corporations, in this book the authors present detailed practical guidelines on the preparation, conduct, design and reporting of case studies of software engineering. This is the first software engineering specific book on the case study research method.

5920.27 рублей

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Cunningham David D. In Vivo Glucose Sensing

In Vivo Glucose Sensing is a key reference for scientists and engineers working on the development of glucose sensing technologies for the management of diabetes and other medical conditions. It discusses the analytical chemistry behind the strategies currently used for measuring glucose in vivo. It focuses on analyzing samples in the real world and discusses the biological complexities that make glucose sensing difficult. Covering current implantable devices, next-generation implantable sensing methods, and non-invasive methods for measuring glucose, this book concludes with an overview of possible applications other than diabetes.

10728.48 рублей

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Tung-Hu Tsai Applications of Microdialysis in Pharmaceutical Science

Discover new and emerging applications for microdialysis in drug evaluation Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces. This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research. Applications of Microdialysis in Pharmaceutical Science starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include: Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases Continuous measurement of glucose concentrations in diabetics Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.

13100.24 рублей

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A much-needed guide to in vitro food functionality evaluation principles, processes, and state-of-the-art modeling There are more than a few books devoted to the assessment of food functionality but, until now, there were no comprehensive guides focusing on the increasingly important subject of in vitro food evaluation. With contributions from the world’s foremost experts in the field, this book brings readers up to speed on the state-of-the-art in in vitro modeling, from its physiological bases to its conception, current uses, and future developments. Food functionality is a broad concept encompassing nutritional and health functionality, food safety and toxicology, as well as a broad range of visual and organoleptic properties of food. In vitro techniques bridge the gap between standard analytical techniques, including chemical and biochemical approaches and in vivo human testing, which remains the ultimate translational goal for evaluation of the functionality of food. Although it is a well- established field, in vitro food testing continues to evolve toward ever more accurate predictions of in vivo properties and outcomes. Both ethical and highly economical, these approaches allow for detailed mechanistic insights into food functionalities and, therefore, a better understanding of the interactions of food and human physiology. Reviews the core concepts of food functionality and functionality evaluation methodologies Provides an overview of the physiology of the gastrointestinal tract, including host-microbial interactions within it Delves into the physiology of sensory perception of food, taste and texture as they relate to in vitro modeling Explores the challenges of linking in vitro analysis of taste, aroma and flavor to their actual perception Addresses in vitro models of the digestion and absorption of macronutrients, micronutrients, and phytonutrients Describes in vitro evaluations of toxicants, allergens and other specific food hazards Functional Foods and Beverages is an indispensable working resource for food scientists as well as researchers working in government facilities dedicated to tracking food safety.

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