varish ahmad qazi mohd sajid jamal and mohd sajid khan phylogenetic analysis and homology modeling of bacteriocin

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Lieberman Bruce S. Phylogenetics. Theory and Practice of Phylogenetic Systematics

The long-awaited revision of the industry standard on phylogenetics Since the publication of the first edition of this landmark volume more than twenty-five years ago, phylogenetic systematics has taken its place as the dominant paradigm of systematic biology. It has profoundly influenced the way scientists study evolution, and has seen many theoretical and technical advances as the field has continued to grow. It goes almost without saying that the next twenty-five years of phylogenetic research will prove as fascinating as the first, with many exciting developments yet to come. This new edition of Phylogenetics captures the very essence of this rapidly evolving discipline. Written for the practicing systematist and phylogeneticist, it addresses both the philosophical and technical issues of the field, as well as surveys general practices in taxonomy. Major sections of the book deal with the nature of species and higher taxa, homology and characters, trees and tree graphs, and biogeography—the purpose being to develop biologically relevant species, character, tree, and biogeographic concepts that can be applied fruitfully to phylogenetics. The book then turns its focus to phylogenetic trees, including an in-depth guide to tree-building algorithms. Additional coverage includes: Parsimony and parsimony analysis Parametric phylogenetics including maximum likelihood and Bayesian approaches Phylogenetic classification Critiques of evolutionary taxonomy, phenetics, and transformed cladistics Specimen selection, field collecting, and curating Systematic publication and the rules of nomenclature Providing a thorough synthesis of the field, this important update to Phylogenetics is essential for students and researchers in the areas of evolutionary biology, molecular evolution, genetics and evolutionary genetics, paleontology, physical anthropology, and zoology.

8502.32 рублей

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Vera Pawlowsky-Glahn Modeling and Analysis of Compositional Data

Modeling and Analysis of Compositional Data presents a practical and comprehensive introduction to the analysis of compositional data along with numerous examples to illustrate both theory and application of each method. Based upon short courses delivered by the authors, it provides a complete and current compendium of fundamental to advanced methodologies along with exercises at the end of each chapter to improve understanding, as well as data and a solutions manual which is available on an accompanying website. Complementing Pawlowsky-Glahn’s earlier collective text that provides an overview of the state-of-the-art in this field, Modeling and Analysis of Compositional Data fills a gap in the literature for a much-needed manual for teaching, self learning or consulting.

8173.27 рублей

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Edward Bodmer Corporate and Project Finance Modeling. Theory and Practice

A clear and comprehensive guide to financial modeling and valuation with extensive case studies and practice exercises Corporate and Project Finance Modeling takes a clear, coherent approach to a complex and technical topic. Written by a globally-recognized financial and economic consultant, this book provides a thorough explanation of financial modeling and analysis while describing the practical application of newly-developed techniques. Theoretical discussion, case studies and step-by-step guides allow readers to master many difficult modeling problems and also explain how to build highly structured models from the ground up. The companion website includes downloadable examples, templates, and hundreds of exercises that allow readers to immediately apply the complex ideas discussed. Financial valuation is an in-depth process, involving both objective and subjective parameters. Precise modeling is critical, and thorough, accurate analysis is what bridges the gap from model to value. This book allows readers to gain a true mastery of the principles underlying financial modeling and valuation by helping them to: Develop flexible and accurate valuation analysis incorporating cash flow waterfalls, depreciation and retirements, updates for new historic periods, and dynamic presentation of scenario and sensitivity analysis; Build customized spreadsheet functions that solve circular logic arising in project and corporate valuation without cumbersome copy and paste macros; Derive accurate measures of normalized cash flow and implied valuation multiples that account for asset life, changing growth, taxes, varying returns and cost of capital; Incorporate stochastic analysis with alternative time series equations and Monte Carlo simulation without add-ins; Understand valuation effects of debt sizing, sculpting, project funding, re-financing, holding periods and credit enhancements. Corporate and Project Finance Modeling provides comprehensive guidance and extensive explanation, making it essential reading for anyone in the field.

4150.9 рублей

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Andrew Sage P. Risk Modeling, Assessment, and Management

Presents systems-based theory, methodology, and applications in risk modeling, assessment, and management This book examines risk analysis, focusing on quantifying risk and constructing probabilities for real-world decision-making, including engineering, design, technology, institutions, organizations, and policy. The author presents fundamental concepts (hierarchical holographic modeling; state space; decision analysis; multi-objective trade-off analysis) as well as advanced material (extreme events and the partitioned multi-objective risk method; multi-objective decision trees; multi-objective risk impact analysis method; guiding principles in risk analysis); avoids higher mathematics whenever possible; and reinforces the material with examples and case studies. The book will be used in systems engineering, enterprise risk management, engineering management, industrial engineering, civil engineering, and operations research. The fourth edition of Risk Modeling, Assessment, and Management features: Expanded chapters on systems-based guiding principles for risk modeling, planning, assessment, management, and communication; modeling interdependent and interconnected complex systems of systems with phantom system models; and hierarchical holographic modeling An expanded appendix including a Bayesian analysis for the prediction of chemical carcinogenicity, and the Farmer’s Dilemma formulated and solved using a deterministic linear model Updated case studies including a new case study on sequential Pareto-optimal decisions for emergent complex systems of systems A new companion website with over 200 solved exercises that feature risk analysis theories, methodologies, and application Risk Modeling, Assessment, and Management, Fourth Edition, is written for both undergraduate and graduate students in systems engineering and systems management courses. The text also serves as a resource for academic, industry, and government professionals in the fields of homeland and cyber security, healthcare, physical infrastructure systems, engineering, business, and more.

12372.67 рублей

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Mike Cheung W.-L. Meta-Analysis. A Structural Equation Modeling Approach

Presents a novel approach to conducting meta-analysis using structural equation modeling. Structural equation modeling (SEM) and meta-analysis are two powerful statistical methods in the educational, social, behavioral, and medical sciences. They are often treated as two unrelated topics in the literature. This book presents a unified framework on analyzing meta-analytic data within the SEM framework, and illustrates how to conduct meta-analysis using the metaSEM package in the R statistical environment. Meta-Analysis: A Structural Equation Modeling Approach begins by introducing the importance of SEM and meta-analysis in answering research questions. Key ideas in meta-analysis and SEM are briefly reviewed, and various meta-analytic models are then introduced and linked to the SEM framework. Fixed-, random-, and mixed-effects models in univariate and multivariate meta-analyses, three-level meta-analysis, and meta-analytic structural equation modeling, are introduced. Advanced topics, such as using restricted maximum likelihood estimation method and handling missing covariates, are also covered. Readers will learn a single framework to apply both meta-analysis and SEM. Examples in R and in Mplus are included. This book will be a valuable resource for statistical and academic researchers and graduate students carrying out meta-analyses, and will also be useful to researchers and statisticians using SEM in biostatistics. Basic knowledge of either SEM or meta-analysis will be helpful in understanding the materials in this book.

4609.87 рублей

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Antonin Dvorak Insight into Fuzzy Modeling

Provides a unique and methodologically consistent treatment of various areas of fuzzy modeling and includes the results of mathematical fuzzy logic and linguistics This book is the result of almost thirty years of research on fuzzy modeling. It provides a unique view of both the theory and various types of applications. The book is divided into two parts. The first part contains an extensive presentation of the theory of fuzzy modeling. The second part presents selected applications in three important areas: control and decision-making, image processing, and time series analysis and forecasting. The authors address the consistent and appropriate treatment of the notions of fuzzy sets and fuzzy logic and their applications. They provide two complementary views of the methodology, which is based on fuzzy IF-THEN rules. The first, more traditional method involves fuzzy approximation and the theory of fuzzy relations. The second method is based on a combination of formal fuzzy logic and linguistics. A very important topic covered for the first time in book form is the fuzzy transform (F-transform). Applications of this theory are described in separate chapters and include image processing and time series analysis and forecasting. All of the mentioned components make this book of interest to students and researchers of fuzzy modeling as well as to practitioners in industry. Features: Provides a foundation of fuzzy modeling and proposes a thorough description of fuzzy modeling methodology Emphasizes fuzzy modeling based on results in linguistics and formal logic Includes chapters on natural language and approximate reasoning, fuzzy control and fuzzy decision-making, and image processing using the F-transform Discusses fuzzy IF-THEN rules for approximating functions, fuzzy cluster analysis, and time series forecasting Insight into Fuzzy Modeling is a reference for researchers in the fields of soft computing and fuzzy logic as well as undergraduate, master and Ph.D. students. Vilém Novák, D.Sc. is Full Professor and Director of the Institute for Research and Applications of Fuzzy Modeling, University of Ostrava, Czech Republic. Irina Perfilieva, Ph.D. is Full Professor, Senior Scientist, and Head of the Department of Theoretical Research at the Institute for Research and Applications of Fuzzy Modeling, University of Ostrava, Czech Republic. Antonín Dvorák, Ph.D. is Associate Professor, and Senior Scientist at the Institute for Research and Applications of Fuzzy Modeling, University of Ostrava, Czech Republic.

8997.79 рублей

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Tony UcedaVelez Risk Centric Threat Modeling. Process for Attack Simulation and Threat Analysis

This book introduces the Process for Attack Simulation & Threat Analysis (PASTA) threat modeling methodology. It provides an introduction to various types of application threat modeling and introduces a risk-centric methodology aimed at applying security countermeasures that are commensurate to the possible impact that could be sustained from defined threat models, vulnerabilities, weaknesses, and attack patterns. This book describes how to apply application threat modeling as an advanced preventive form of security. The authors discuss the methodologies, tools, and case studies of successful application threat modeling techniques. Chapter 1 provides an overview of threat modeling, while Chapter 2 describes the objectives and benefits of threat modeling. Chapter 3 focuses on existing threat modeling approaches, and Chapter 4 discusses integrating threat modeling within the different types of Software Development Lifecycles (SDLCs). Threat modeling and risk management is the focus of Chapter 5. Chapter 6 and Chapter 7 examine Process for Attack Simulation and Threat Analysis (PASTA). Finally, Chapter 8 shows how to use the PASTA risk-centric threat modeling process to analyze the risks of specific threat agents targeting web applications. This chapter focuses specifically on the web application assets that include customer’s confidential data and business critical functionality that the web application provides. • Provides a detailed walkthrough of the PASTA methodology alongside software development activities, normally conducted via a standard SDLC process • Offers precise steps to take when combating threats to businesses • Examines real-life data breach incidents and lessons for risk management Risk Centric Threat Modeling: Process for Attack Simulation and Threat Analysis is a resource for software developers, architects, technical risk managers, and seasoned security professionals.

8247.97 рублей

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Eric Johnson R. Handbook of Decision Analysis

A ONE-OF-A-KIND GUIDE TO THE BEST PRACTICES IN DECISION ANALYSIS Decision analysis provides powerful tools for addressing complex decisions that involve uncertainty and multiple objectives, yet most training materials on the subject overlook the soft skills that are essential for success in the field. This unique resource fills this gap in the decision analysis literature and features both soft personal/interpersonal skills and the hard technical skills involving mathematics and modeling. Readers will learn how to identify and overcome the numerous challenges of decision making, choose the appropriate decision process, lead and manage teams, and create value for their organization. Performing modeling analysis, assessing risk, and implementing decisions are also addressed throughout. Additional features include: Key insights gleaned from decision analysis applications and behavioral decision analysis research Integrated coverage of the techniques of single- and multiple-objective decision analysis Multiple qualitative and quantitative techniques presented for each key decision analysis task Three substantive real-world case studies illustrating diverse strategies for dealing with the challenges of decision making Extensive references for mathematical proofs and advanced topics The Handbook of Decision Analysis is an essential reference for academics and practitioners in various fields including business, operations research, engineering, and science. The book also serves as a supplement for courses at the upper-undergraduate and graduate levels.

12372.67 рублей

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Matthew Thompson Natural Hazard Uncertainty Assessment. Modeling and Decision Support

Uncertainties are pervasive in natural hazards, and it is crucial to develop robust and meaningful approaches to characterize and communicate uncertainties to inform modeling efforts. In this monograph we provide a broad, cross-disciplinary overview of issues relating to uncertainties faced in natural hazard and risk assessment. We introduce some basic tenets of uncertainty analysis, discuss issues related to communication and decision support, and offer numerous examples of analyses and modeling approaches that vary by context and scope. Contributors include scientists from across the full breath of the natural hazard scientific community, from those in real-time analysis of natural hazards to those in the research community from academia and government. Key themes and highlights include: Substantial breadth and depth of analysis in terms of the types of natural hazards addressed, the disciplinary perspectives represented, and the number of studies included Targeted, application-centered analyses with a focus on development and use of modeling techniques to address various sources of uncertainty Emphasis on the impacts of climate change on natural hazard processes and outcomes Recommendations for cross-disciplinary and science transfer across natural hazard sciences This volume will be an excellent resource for those interested in the current work on uncertainty classification/quantification and will document common and emergent research themes to allow all to learn from each other and build a more connected but still diverse and ever growing community of scientists.

11243.68 рублей

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Jinghong Fan Multiscale Analysis of Deformation and Failure of Materials

Presenting cutting-edge research and development within multiscale modeling techniques and frameworks, Multiscale Analysis of Deformation and Failure of Materials systematically describes the background, principles and methods within this exciting new & interdisciplinary field. The author’s approach emphasizes the principles and methods of atomistic simulation and its transition to the nano and sub-micron scale of a continuum, which is technically important for nanotechnology and biotechnology. He also pays close attention to multiscale analysis across the micro/meso/macroscopy of a continuum, which has a broad scope of applications encompassing different disciplines and practices, and is an essential extension of mesomechanics. Of equal interest to engineers, scientists, academics and students, Multiscale Analysis of Deformation and Failure of Materials is a multidisciplinary text relevant to those working in the areas of materials science, solid and computational mechanics, bioengineering and biomaterials, and aerospace, automotive, civil, and environmental engineering. Provides a deep understanding of multiscale analysis and its implementation Shows in detail how multiscale models can be developed from practical problems and how to use the multiscale methods and software to carry out simulations Discusses two interlinked categories of multiscale analysis; analysis spanning from the atomistic to the micro-continuum scales, and analysis across the micro/meso/macro scale of continuum.

10872.33 рублей

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Jinghong Fan Multiscale Analysis of Deformation and Failure of Materials

Presenting cutting-edge research and development within multiscale modeling techniques and frameworks, Multiscale Analysis of Deformation and Failure of Materials systematically describes the background, principles and methods within this exciting new & interdisciplinary field. The author’s approach emphasizes the principles and methods of atomistic simulation and its transition to the nano and sub-micron scale of a continuum, which is technically important for nanotechnology and biotechnology. He also pays close attention to multiscale analysis across the micro/meso/macroscopy of a continuum, which has a broad scope of applications encompassing different disciplines and practices, and is an essential extension of mesomechanics. Of equal interest to engineers, scientists, academics and students, Multiscale Analysis of Deformation and Failure of Materials is a multidisciplinary text relevant to those working in the areas of materials science, solid and computational mechanics, bioengineering and biomaterials, and aerospace, automotive, civil, and environmental engineering. Provides a deep understanding of multiscale analysis and its implementation Shows in detail how multiscale models can be developed from practical problems and how to use the multiscale methods and software to carry out simulations Discusses two interlinked categories of multiscale analysis; analysis spanning from the atomistic to the micro-continuum scales, and analysis across the micro/meso/macro scale of continuum.

11111.64 рублей

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Wang Jichuan Structural Equation Modeling. Applications Using Mplus

A reference guide for applications of SEM using Mplus Structural Equation Modeling: Applications Using Mplus is intended as both a teaching resource and a reference guide. Written in non-mathematical terms, this book focuses on the conceptual and practical aspects of Structural Equation Modeling (SEM). Basic concepts and examples of various SEM models are demonstrated along with recently developed advanced methods, such as mixture modeling and model-based power analysis and sample size estimate for SEM. The statistical modeling program, Mplus, is also featured and provides researchers with a flexible tool to analyze their data with an easy-to-use interface and graphical displays of data and analysis results. Key features: Presents a useful reference guide for applications of SEM whilst systematically demonstrating various advanced SEM models, such as multi-group and mixture models using Mplus. Discusses and demonstrates various SEM models using both cross-sectional and longitudinal data with both continuous and categorical outcomes. Provides step-by-step instructions of model specification and estimation, as well as detail interpretation of Mplus results. Explores different methods for sample size estimate and statistical power analysis for SEM. By following the examples provided in this book, readers will be able to build their own SEM models using Mplus. Teachers, graduate students, and researchers in social sciences and health studies will also benefit from this book.

8965.94 рублей

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Sanjay Ranka Modeling and Optimization of Parallel and Distributed Embedded Systems

This book introduces the state-of-the-art in research in parallel and distributed embedded systems, which have been enabled by developments in silicon technology, micro-electro-mechanical systems (MEMS), wireless communications, computer networking, and digital electronics. These systems have diverse applications in domains including military and defense, medical, automotive, and unmanned autonomous vehicles. The emphasis of the book is on the modeling and optimization of emerging parallel and distributed embedded systems in relation to the three key design metrics of performance, power and dependability. Key features: Includes an embedded wireless sensor networks case study to help illustrate the modeling and optimization of distributed embedded systems. Provides an analysis of multi-core/many-core based embedded systems to explain the modeling and optimization of parallel embedded systems. Features an application metrics estimation model; Markov modeling for fault tolerance and analysis; and queueing theoretic modeling for performance evaluation. Discusses optimization approaches for distributed wireless sensor networks; high-performance and energy-efficient techniques at the architecture, middleware and software levels for parallel multicore-based embedded systems; and dynamic optimization methodologies. Highlights research challenges and future research directions. The book is primarily aimed at researchers in embedded systems; however, it will also serve as an invaluable reference to senior undergraduate and graduate students with an interest in embedded systems research.

10497.42 рублей

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Jianhong Wu Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases

Features modern research and methodology on the spread of infectious diseases and showcases a broad range of multi-disciplinary and state-of-the-art techniques on geo-simulation, geo-visualization, remote sensing, metapopulation modeling, cloud computing, and pattern analysis Given the ongoing risk of infectious diseases worldwide, it is crucial to develop appropriate analysis methods, models, and tools to assess and predict the spread of disease and evaluate the risk. Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases features mathematical and spatial modeling approaches that integrate applications from various fields such as geo-computation and simulation, spatial analytics, mathematics, statistics, epidemiology, and health policy. In addition, the book captures the latest advances in the use of geographic information system (GIS), global positioning system (GPS), and other location-based technologies in the spatial and temporal study of infectious diseases. Highlighting the current practices and methodology via various infectious disease studies, Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases features: Approaches to better use infectious disease data collected from various sources for analysis and modeling purposes Examples of disease spreading dynamics, including West Nile virus, bird flu, Lyme disease, pandemic influenza (H1N1), and schistosomiasis Modern techniques such as Smartphone use in spatio-temporal usage data, cloud computing-enabled cluster detection, and communicable disease geo-simulation based on human mobility An overview of different mathematical, statistical, spatial modeling, and geo-simulation techniques Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases is an excellent resource for researchers and scientists who use, manage, or analyze infectious disease data, need to learn various traditional and advanced analytical methods and modeling techniques, and become aware of different issues and challenges related to infectious disease modeling and simulation. The book is also a useful textbook and/or supplement for upper-undergraduate and graduate-level courses in bioinformatics, biostatistics, public health and policy, and epidemiology.

10497.42 рублей

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Michael Bell SOA Modeling Patterns for Service Oriented Discovery and Analysis

Learn the essential tools for developing a sound service-oriented architecture SOA Modeling Patterns for Service-Oriented Discovery and Analysis introduces a universal, easy-to-use, and nimble SOA modeling language to facilitate the service identification and examination life cycle stage. This business and technological vocabulary will benefit your service development endeavors and foster organizational software asset reuse and consolidation, and reduction of expenditure. Whether you are a developer, business architect, technical architect, modeler, business analyst, team leader, or manager, this essential guide-introducing an elaborate set of more than 100 patterns and anti-patterns-will help you successfully discover and analyze services, and model a superior solution for your project,. Explores how to discover services Explains how to analyze services for construction and production How to assess service feasibility for deployment How to employ the SOA modeling language during the service identification and examination process How to utilize the SOA modeling patterns and anti-patterns for service discovery and analysis Focusing on the Service-Oriented Discovery and Analysis Life Cycle Stage, this book will help you acquire a broad SOA Modeling knowledge base and leverage that to increase efficiency and productivity in the workplace.

4150.9 рублей

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Jamal Daafouz Hybrid Systems with Constraints

Control theory is the main subject of this title, in particular analysis and control design for hybrid dynamic systems. The notion of hybrid systems offers a strong theoretical and unified framework to cope with the modeling, analysis and control design of systems where both continuous and discrete dynamics interact. The theory of hybrid systems has been the subject of intensive research over the last decade and a large number of diverse and challenging problems have been investigated. Nevertheless, many important mathematical problems remain open. This book is dedicated mainly to hybrid systems with constraints; taking constraints into account in a dynamic system description has always been a critical issue in control. New tools are provided here for stability analysis and control design for hybrid systems with operating constraints and performance specifications. Contents 1. Positive Systems: Discretization with Positivity and Constraints, Patrizio Colaneri, Marcello Farina, Stephen Kirkland, Riccardo Scattolini and Robert Shorten. 2. Advanced Lyapunov Functions for Lur’e Systems, Carlos A. Gonzaga, Marc Jungers and Jamal Daafouz. 3. Stability of Switched DAEs, Stephan Trenn. 4. Stabilization of Persistently Excited Linear Systems, Yacine Chitour, Guilherme Mazanti and Mario Sigalotti. 5. Hybrid Coordination of Flow Networks, Claudio De Persis, Paolo Frasca. 6. Control of Hybrid Systems: An Overview of Recent Advances, Ricardo G. Sanfelice. 7. Exponential Stability for Hybrid Systems with Saturations, Mirko Fiacchini, Sophie Tarbouriech, Christophe Prieur. 8. Reference Mirroring for Control with Impacts, Fulvio Forni, Andrew R. Teel, Luca Zaccarian. About the Authors Jamal Daafouz is an expert in the area of switched and polytopic systems and has published several major results in leading journals (IEEE TAC, Automatica, Systems and Control Letters, etc.). He serves as an Associate Editor for the key journal IEEE TAC and is a member of the Editorial Board of the IEEE CSS society. Sophie Tarbouriech is an expert in the area of nonlinear systems with constraints and has published several major results in leading journals (IEEE TAC, Automatica, Systems and Control Letters, etc.) and books. She is a member of the Editorial Board of the IEEE CSS society and has also served as an Associate Editor for the key journal IEEE TAC. Mario Sigalotti is an expert in applied mathematics and switched systems and has published several results in leading journals (IEEE TAC, Automatica, Systems and Control Letters, etc.). He heads the INRIA team GECO and is a member of the IFAC Technical Committee on Distributed Parameter Systems.

9972.41 рублей

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Stephen W. Freiman The Fracture of Brittle Materials. Testing and Analysis

Provides a modern, practical approach to the understanding and measurement procedures relevant to the fracture of brittle materials This book examines the testing and analysis of the fracture of brittle materials. Expanding on the measurement and analysis methodology contained in the first edition, it covers the relevant measurements (toughness and strength), material types, fracture mechanics, measurement techniques, reliability and lifetime predictions, microstructural considerations, and material/test selection processes appropriate for the analysis of the fracture behavior of brittle materials. The Fracture of Brittle Materials: Testing and Analysis, Second Edition summarizes the concepts behind the selection of a test procedure for fracture toughness and strength, and goes into detail on how the statistics of fracture can be used to assure reliability. It explains the importance of the role of microstructure in these determinations and emphasizes the use of fractographic analysis as an important tool in understanding why a part failed. The new edition includes a significant quantity of material related to the fracture of biomaterials, and features two new chapters—one on thermal shock, the other on the modeling of the fracture process. It also expands on a discussion of how to treat the statistics of fracture strength data to ensure reliability. Provides practical analysis of fracture toughness and strength Introduces the engineering and materials student to the basic concepts necessary for analyzing brittle fracture Contains new statistical analysis procedures to allow for the prediction of the safe design of brittle components Contains real-world examples to assist the reader in applying the concepts to their own research, material development, and quality-control needs The Fracture of Brittle Materials: Testing and Analysis, Second Edition is an important resource for all students, technicians, engineers, scientists, and researchers involved in the study, analysis, creation, or testing of ceramics.

9579 рублей

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Jill Fiedler-Kelly Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models

This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website

8548.18 рублей

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Control theory is the main subject of this title, in particular analysis and control design for hybrid dynamic systems. The notion of hybrid systems offers a strong theoretical and unified framework to cope with the modeling, analysis and control design of systems where both continuous and discrete dynamics interact. The theory of hybrid systems has been the subject of intensive research over the last decade and a large number of diverse and challenging problems have been investigated. Nevertheless, many important mathematical problems remain open. This book is dedicated mainly to hybrid systems with constraints; taking constraints into account in a dynamic system description has always been a critical issue in control. New tools are provided here for stability analysis and control design for hybrid systems with operating constraints and performance specifications. Contents 1. Positive Systems: Discretization with Positivity and Constraints, Patrizio Colaneri, Marcello Farina, Stephen Kirkland, Riccardo Scattolini and Robert Shorten. 2. Advanced Lyapunov Functions for Lur’e Systems, Carlos A. Gonzaga, Marc Jungers and Jamal Daafouz. 3. Stability of Switched DAEs, Stephan Trenn. 4. Stabilization of Persistently Excited Linear Systems, Yacine Chitour, Guilherme Mazanti and Mario Sigalotti. 5. Hybrid Coordination of Flow Networks, Claudio De Persis, Paolo Frasca. 6. Control of Hybrid Systems: An Overview of Recent Advances, Ricardo G. Sanfelice. 7. Exponential Stability for Hybrid Systems with Saturations, Mirko Fiacchini, Sophie Tarbouriech, Christophe Prieur. 8. Reference Mirroring for Control with Impacts, Fulvio Forni, Andrew R. Teel, Luca Zaccarian. About the Authors Jamal Daafouz is an expert in the area of switched and polytopic systems and has published several major results in leading journals (IEEE TAC, Automatica, Systems and Control Letters, etc.). He serves as an Associate Editor for the key journal IEEE TAC and is a member of the Editorial Board of the IEEE CSS society. Sophie Tarbouriech is an expert in the area of nonlinear systems with constraints and has published several major results in leading journals (IEEE TAC, Automatica, Systems and Control Letters, etc.) and books. She is a member of the Editorial Board of the IEEE CSS society and has also served as an Associate Editor for the key journal IEEE TAC. Mario Sigalotti is an expert in applied mathematics and switched systems and has published several results in leading journals (IEEE TAC, Automatica, Systems and Control Letters, etc.). He heads the INRIA team GECO and is a member of the IFAC Technical Committee on Distributed Parameter Systems.

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