sumeet gullaiya and swati madan doxorubicin induced cardiotoxicity the spice retreat

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Giorgio Minotti Cardiotoxicity of Non-Cardiovascular Drugs

Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.

13487.23 рублей

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Scott Cooper P. Atlas of Natural and Induced Fractures in Core

An invaluable reference that helps geologists recognize and differentiate the many types of natural fractures, induced fractures and artefacts found in cores Atlas of Natural and Induced Fractures in Core offers a reference for the interpretation of natural and induced fractures in cores. The natural and induced fracture data contained in cores provides a wealth of information once they are recognized and properly interpreted. Written by two experts in the field, this resource provides a much-needed tool to help with the accurate interpretation of these cores. The authorsinclude the information needed to identify different fracture types as well as the criteria for distinguishing between the types of fractures. The atlas shows how to recognize non-fracture artefacts in a core since many of them provide other types of useful information. In addition, the text’s illustrated structures combined with their basic interpretations are designed to be primary building blocks of a complete fracture assessment and analysis. The authors show how to recognize and correctly interpret these building blocks to ensure that subsequent analyses, interpretations, and modeling efforts regarding fracture-controlled reservoir permeability are valid. Presented in full color throughout, this comprehensive reference is written for geologists charged with interpreting fracture-controlled permeability systems in reservoirs as well as for students or other scientists who need to develop the skills to accurately interpret the natural and induced fractures in cores.

11247.23 рублей

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Anjun Qin Aggregation-Induced Emission. Fundamentals

Aggregation-Induced Emission (AIE) is a novel photophysical phenomenon which offers a new platform for researchers to look into the light-emitting processes from luminogen aggregates, from which useful information on structure–property relationships may be collected and mechanistic insights may be gained. The discovery of the AIE effect opens a new avenue for the development of new luminogen materials in the aggregate or solid state. By enabling light emission in the practically useful solid state, AIE has the potential to expand significantly the technological applications of luminescent materials. Aggregation-Induced Emission: Fundamentals is the first book to explore the fundamental issues of AIE, including the design, synthesis, and photophysical behavior of AIE-active molecules and polymers. The control of the morphological structures of the aggregates of AIE-active materials, and the experimental investigation and theoretical understanding of the AIE mechanism, are also covered in this volume. Topics covered include: AIE in group 14 metalloles AIE in organic ion pairs Red light-emitting AIE materials Supramolecular structure and AIE AIE-active polymers Enhanced emission by restriction of molecular rotation Crystallization-induced emission enhancement Theoretical understanding of AIE phenomena This book is essential reading for scientists and engineers who are designing optoelectronic materials and biomedical sensors, and will also be of interest to academic researchers in materials science and physical and synthetic organic chemistry, as well as physicists and biological chemists.

16646.05 рублей

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Sumeet Desai What You Need to Know about Economics

George Buckley & Sumeet Desai: What You Need To Know About Economics Economics Matters. But with confusing things like GDP and interest rates, it’s often hard to get you head around. So What do you really need to know about economics? Find out: What economic growth is and why it matters How inflation happens How jobs are created and lost How the property market works What central banks do and how it affects the rest of us The impact of government spending on the economy What You Need to Know About Economics cuts through the theory to help you to do your job and understand the world around you better. Read More in the What You Need to Know Series and Ger Up to Speed on The Essentials… Fast.

1594.99 рублей

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Yehuda Shoenfeld Vaccines and Autoimmunity

In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

12744.02 рублей

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Qiuhong Tang Terrestrial Water Cycle and Climate Change. Natural and Human-Induced Impacts

The Terrestrial Water Cycle: Natural and Human-Induced Changes is a comprehensive volume that investigates the changes in the terrestrial water cycle and the natural and anthropogenic factors that cause these changes. This volume brings together recent progress and achievements in large-scale hydrological observations and numerical simulations, specifically in areas such as in situ measurement network, satellite remote sensing and hydrological modeling. Our goal is to extend and deepen our understanding of the changes in the terrestrial water cycle and to shed light on the mechanisms of the changes and their consequences in water resources and human well-being in the context of global change. Volume highlights include: Overview of the changes in the terrestrial water cycle Human alterations of the terrestrial water cycle Recent advances in hydrological measurement and observation Integrated modeling of the terrestrial water cycle The Terrestrial Water Cycle: Natural and Human-Induced Changes will be a valuable resource for students and professionals in the fields of hydrology, water resources, climate change, ecology, geophysics, and geographic sciences. The book will also be attractive to those who have general interests in the terrestrial water cycle, including how and why the cycle changes.

13932.06 рублей

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You-Lin Xu Wind Effects on Cable-Supported Bridges

As an in-depth guide to understanding wind effects on cable-supported bridges, this book uses analytical, numerical and experimental methods to give readers a fundamental and practical understanding of the subject matter. It is structured to systemically move from introductory areas through to advanced topics currently being developed from research work. The author concludes with the application of the theory covered to real-world examples, enabling readers to apply their knowledge. The author provides background material, covering areas such as wind climate, cable-supported bridges, wind-induced damage, and the history of bridge wind engineering. Wind characteristics in atmospheric boundary layer, mean wind load and aerostatic instability, wind-induced vibration and aerodynamic instability, and wind tunnel testing are then described as the fundamentals of the subject. State-of-the-art contributions include rain-wind-induced cable vibration, wind-vehicle-bridge interaction, wind-induced vibration control, wind and structural health monitoring, fatigue analysis, reliability analysis, typhoon wind simulation, non-stationary and nonlinear buffeting response. Lastly, the theory is applied to the actual long-span cable-supported bridges. Structured in an easy-to-follow way, covering the topic from the fundamentals right through to the state-of-the-art Describes advanced topics such as wind and structural health monitoring and non-stationary and nonlinear buffeting response Gives a comprehensive description of various methods including CFD simulations of bridge and vehicle loading Uses two projects with which the author has worked extensively, Stonecutters cable-stayed bridge and Tsing Ma suspension bridge, as worked examples, giving readers a practical understanding

15399.2 рублей

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Alex Cramer Cooking with spice mixes, pastes and sauces

This cookbook is about the art of mixing herbs and spices.– You will get acquainted with the main theory of mixing the spices and herbs.– You will discover the 35 most popular spices and herbs.– You will find out a description of the 35 most popular varieties of chili peppers.– You will learn many more useful information.And finally you will plunge into the world of spicy combinations and get acquainted with the recipes of more than 300 dry spice mixes, pastes and sauces, as well as their variations.Step by step you will learn the art of fragrant spice balance and the taste's magic of spicy combinations!

249 рублей

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Артур Конан Дойл The Sign of the Four

Sherlock Holmes is sitting in a cocaine-induced haze until the arrival of a distressed and beautiful young lady forces the great detective into action. Each year following the strange disappearance of her father, Miss Morstan has received a present of a rare and lustrous pearl. Now, on the day she is summoned to meet her anonymous benefactor, she consults Holmes and Watson.

0 рублей

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Misha Gorfunkle Mechanics of Fluid Flow

The mechanics of fluid flow is a fundamental engineering discipline explaining both natural phenomena and human-induced processes, and a thorough understanding of it is central to the operations of the oil and gas industry. This book, written by some of the world’s best-known and respected petroleum engineers, covers the concepts, theories, and applications of the mechanics of fluid flow for the veteran engineer working in the field and the student, alike. It is a must-have for any engineer working in the oil and gas industry.

15896.23 рублей

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Lenora Worth Something Beautiful and Lacey's Retreat: Something Beautiful / Lacey's Retreat

Something BeautifulShe was the kind of woman who could make Lucas Dorsette change his wild ways. But Willa O'Connor had a life-threatening secret and trust wasn't easy. She needed something more– and Lucas hoped his love was the answer to her prayers.Lacey's RetreatRunning, bleeding and desperate, Gavin Prescott found sanctuary in a New Orleans church and hope in Lacey Dorsette York. Lacey was willing to risk everything, but was Gavin's love a path to danger…or to God's plan?

593.31 рублей

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Wildside. The Enchanted Life of Hunters and Gatherers

The woods are alive with possibilities: Retreat into nature, meet mushroom pickers, collectors, and explorers. Build cabins and scenic trails, create crafts, or start...

4670 рублей

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As an in-depth guide to understanding wind effects on cable-supported bridges, this book uses analytical, numerical and experimental methods to give readers a fundamental and practical understanding of the subject matter. It is structured to systemically move from introductory areas through to advanced topics currently being developed from research work. The author concludes with the application of the theory covered to real-world examples, enabling readers to apply their knowledge. The author provides background material, covering areas such as wind climate, cable-supported bridges, wind-induced damage, and the history of bridge wind engineering. Wind characteristics in atmospheric boundary layer, mean wind load and aerostatic instability, wind-induced vibration and aerodynamic instability, and wind tunnel testing are then described as the fundamentals of the subject. State-of-the-art contributions include rain-wind-induced cable vibration, wind-vehicle-bridge interaction, wind-induced vibration control, wind and structural health monitoring, fatigue analysis, reliability analysis, typhoon wind simulation, non-stationary and nonlinear buffeting response. Lastly, the theory is applied to the actual long-span cable-supported bridges. Structured in an easy-to-follow way, covering the topic from the fundamentals right through to the state-of-the-art Describes advanced topics such as wind and structural health monitoring and non-stationary and nonlinear buffeting response Gives a comprehensive description of various methods including CFD simulations of bridge and vehicle loading Uses two projects with which the author has worked extensively, Stonecutters cable-stayed bridge and Tsing Ma suspension bridge, as worked examples, giving readers a practical understanding

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