mohammad sohail and mohammad raziuddin role of cytokines in human malaria

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Brian Henderson The Human Microbiota and Chronic Disease. Dysbiosis as a Cause of Human Pathology

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

11243.68 рублей

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William J. Rothwell The Encyclopedia of Human Resource Management, Volume 3

The three volumes in The Encyclopedia of Human Resource Management offer a comprehensive review of the essential issues and most important information available on the topic. Each volume in the encyclopedia contains contributions from some of the most celebrated names in the field of human resource management (HRM) and addresses the myriad challenges faced by today's human resource professionals. Volume 3 highlights three main topics HR professionals have identified as critical issues in today's workplace: Leadership and Learning; Strategy and Measurement; and The Evolution of Human Resources. Many of the articles in this volume provide an in-depth discussion of a current human resource topic while others introduce a new way of approaching a familiar HR challenge. Each article is designed to stimulate critical thinking and reflection. The topics covered include: Best Practices in Leadership Development; Leadership is Going Global; Web 2.0 Applications in Corporate Training; The Social Construction of Productive Organizations; Leadership Versatility; Strategy and Measurement; Strategic Business Partner Role; Human Resource Metrics; The HR Transition to Strategic Partner; Workplace Bullying; Lost Wisdom, Lost ROI; The Role of HR in Fostering Innovation in Organizations; Closing Critical Skills Gaps; Employee Engagement and Corporate Social Responsibility; The Implications of Situational Strength for HRM; and more. The Encyclopedia of Human Resource Management gives human resource professionals the knowledge, information, and tools needed to implement the best practices in the field.

14096.46 рублей

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S. Arifin M.Niaz Spatial Agent-Based Simulation Modeling in Public Health. Design, Implementation, and Applications for Malaria Epidemiology

Presents an overview of the complex biological systems used within a global public health setting and features a focus on malaria analysis Bridging the gap between agent-based modeling and simulation (ABMS) and geographic information systems (GIS), Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology provides a useful introduction to the development of agent-based models (ABMs) by following a conceptual and biological core model of Anopheles gambiae for malaria epidemiology. Using spatial ABMs, the book includes mosquito (vector) control interventions and GIS as two example applications of ABMs, as well as a brief description of epidemiology modeling. In addition, the authors discuss how to most effectively integrate spatial ABMs with a GIS. The book concludes with a combination of knowledge from entomological, epidemiological, simulation-based, and geo-spatial domains in order to identify and analyze relationships between various transmission variables of the disease. Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology also features: Location-specific mosquito abundance maps that play an important role in malaria control activities by guiding future resource allocation for malaria control and identifying hotspots for further investigation Discussions on the best modeling practices in an effort to achieve improved efficacy, cost-effectiveness, ecological soundness, and sustainability of vector control for malaria An overview of the various ABMs, GIS, and spatial statistical methods used in entomological and epidemiological studies, as well as the model malaria study A companion website with computer source code and flowcharts of the spatial ABM and a landscape generator tool that can simulate landscapes with varying spatial heterogeneity of different types of resources including aquatic habitats and houses Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology is an excellent reference for professionals such as modeling and simulation experts, GIS experts, spatial analysts, mathematicians, statisticians, epidemiologists, health policy makers, as well as researchers and scientists who use, manage, or analyze infectious disease data and/or infectious disease-related projects. The book is also ideal for graduate-level courses in modeling and simulation, bioinformatics, biostatistics, public health and policy, and epidemiology.

9372.7 рублей

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Saura Sahu C. microRNAs in Toxicology and Medicine

During the past decade it has become evident that microRNAs regulate gene expressions and control many developmental and cellular processes in eukaryotic organisms. Recent studies suggest that microRNAs play an important role in toxicogenomics and are likely to play an important role in a range of human diseases including cancer. microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of up-to-date developments in this emerging research area, presented by internationally recognized investigators. It focuses on the role of microRNA in biology and medicine with a special emphasis on toxicology. Divided into six parts, topics covered include: microRNA and toxicology – including environmental toxicants and perturbation of miRNA signaling; microRNA, and Disease States featuring microRNAs in drug-induced liver toxicity, microRNAs and Inflammation the regulatory role of microRNA in mutagenesis, microRNAs and cancer, and the role of microRNAs in tumor progression and therapy, as well as current understanding of microRNAs as therapeutic targets in cancer microRNAs and disease states microRNAs and stem cells microRNAs and genomics microRNAs and epigenomics microRNAs and biomarkers – including body fluid microRNAs as toxicological biomarkers, cell-free microRNAs as biomarkers in human diseases, and circulating microRNAs as biomarkers of drug-induced pancreatitis microRNAs in Toxicology and Medicine is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors, and regulators in academia, medical settings, industry, and government.

17171.06 рублей

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Mark Stoneking An Introduction to Molecular Anthropology

Molecular anthropology uses molecular genetic methods to address questions and issues of anthropological interest. More specifically, molecular anthropology is concerned with genetic evidence concerning human origins, migrations, and population relationships, including related topics such as the role of recent natural selection in human population differentiation, or the impact of particular social systems on patterns of human genetic variation. Organized into three major sections, An Introduction to Molecular Anthropology first covers the basics of genetics – what genes are, what they do, and how they do it – as well as how genes behave in populations and how evolution influences them. The following section provides an overview of the different kinds of genetic variation in humans, and how this variation is analyzed and used to make evolutionary inferences. The third section concludes with a presentation of the current state of genetic evidence for human origins, the spread of humans around the world, the role of selection and adaptation in human evolution, and the impact of culture on human genetic variation. A final, concluding chapter discusses various aspects of molecular anthropology in the genomics era, including personal ancestry testing and personal genomics. An Introduction to Molecular Anthropology is an invaluable resource for students studying human evolution, biological anthropology, or molecular anthropology, as well as a reference for anthropologists and anyone else interested in the genetic history of humans.

9744.05 рублей

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Keen Patricia L. Antimicrobial Resistance in the Environment

Examines effects of the environmental distribution of antimicrobial resistance genes on human health and the ecosystem Resistance genes are everywhere in nature—in pathogens, commensals, and environmental microorganisms. This contributed work shows how the environment plays a pivotal role in the development of antimicrobial resistance traits in bacteria and the distribution of resistant microbial species, resistant genetic material, and antibiotic compounds. Readers will discover the impact of the distribution in the environment of antimicrobial resistance genes and antibiotics on both the ecosystem and human and animal health. Antimicrobial Resistance in the Environment is divided into four parts: Part I, Sources, including ecological and clinical consequences of antibiotic resistance by environmental microbes Part II, Fate, including strategies to assess and minimize the biological risk of antibiotic resistance in the environment Part III, Antimicrobial Substances and Resistance, including antibiotics in the aquatic environment Part IV, Effects and Risks, including the effect of antimicrobials used for non-human purposes on human health Recognizing the intricate links among overlapping complex systems, this book examines antimicrobial resistance using a comprehensive ecosystem approach. Moreover, the book's multidisciplinary framework applies principles of microbiology, environmental toxicology, and chemistry to assess the human and ecological risks associated with exposure to antibiotics or antibiotic resistance genes that are environmental contaminants. Each chapter has been written by one or more leading researchers in such fields as microbiology, environmental science, ecology, and toxicology. Comprehensive reference lists at the end of all chapters serve as a gateway to the primary research in the field. Presenting and analyzing the latest findings in a field of growing importance to human and environmental health, this text offers readers new insights into the role of the environment in antimicrobial resistance development, the dissemination of antimicrobial resistant genetic elements, and the transport of antibiotic resistance genes and antibiotics.

11874.13 рублей

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Niamh Reilly Women's Human Rights

Women's Human Rights: Seeking Gender Justice in a Globalising Age explores the emergence of transnational, UN-oriented, feminist advocacy for womens human rights, especially over the past three decades. It identifies the main feminist influences that have shaped the movement liberal, radical, third world and cosmopolitan and exposes how the Western, legalist, state-centric, and liberal biases of mainstream human rights discourse impede the realisation of human rights in womens lives everywhere. The book traces the evolution of the womens human rights movement through an examination of its key issues, debates, and practical interventions in international law and policy arenas. This includes efforts to: Develop global gender equality norms via the UN Womens Convention Frame violence against women as a human rights issue Address gender-based crimes in conflict situations, include women in conflict resolution and post-conflict reconstruction, and challenge new forms of militarism Highlight the gendered human rights dimensions of widening inequalities in a context of neo-liberal globalisation Develop human rights responses to anti-feminist fundamentalist movements with a focus on reproductive and sexual rights Ultimately, Women's Human Rights reaffirms a commitment to critically reinterpreted universal human rights principles and demonstrates the vital role that bottom-up, transnational movements play in making them a reality in women's lives.

5360.41 рублей

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Stewart Kathlyn Human Brain Evolution. The Influence of Freshwater and Marine Food Resources

The evolution of the human brain and cognitive ability is one of the central themes of physical/biological anthropology. This book discusses the emergence of human cognition at a conceptual level, describing it as a process of long adaptive stasis interrupted by short periods of cognitive advance. These advances were not linear and directed, but were acquired indirectly as part of changing human behaviors, in other words through the process of exaptation (acquisition of a function for which it was not originally selected). Based on studies of the modem human brain, certain prerequisites were needed for the development of the early brain and associated cognitive advances. This book documents the energy and nutrient constraints of the modern brain, highlighting the significant role of long-chain polyunsaturated fatty acids (LC-PUFA) in brain development and maintenance. Crawford provides further emphasis for the role of essential fatty acids, in particular DHA, in brain development, by discussing the evolution of the eye and neural systems. This is an ideal book for Graduate students, post docs, research scientists in Physical/Biological Anthropology, Human Biology, Archaeology, Nutrition, Cognitive Science, Neurosciences. It is also an excellent selection for a grad student discussion seminar.

12640.45 рублей

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Campbell Rolian Developmental Approaches to Human Evolution

Developmental Approaches to Human Evolution encapsulates the current state of evolutionary developmental anthropology. This emerging scientific field applies tools and approaches from modern developmental biology to understand the role of genetic and developmental processes in driving morphological and cognitive evolution in humans, non-human primates and in the laboratory organisms used to model these changes. Featuring contributions from well-established pioneers and emerging leaders, this volume is designed to build research momentum and catalyze future innovation in this burgeoning field. The book’s broad research scope encompasses soft and hard tissues of the head and body, including the skeleton, special senses and the brain. Developmental Approaches to Human Evolution is an invaluable resource on the mechanisms of primate and vertebrate evolution for scholars across a wide array of intersecting disciplines, including primatology, paleoanthropology, vertebrate morphology, evolutionary developmental biology and health sciences.

9744.05 рублей

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More Max The Transhumanist Reader. Classical and Contemporary Essays on the Science, Technology, and Philosophy of the Human Future

The first authoritative and comprehensive survey of the origins and current state of transhumanist thinking The rapid pace of emerging technologies is playing an increasingly important role in overcoming fundamental human limitations. Featuring core writings by seminal thinkers in the speculative possibilities of the posthuman condition, essays address key philosophical arguments for and against human enhancement, explore the inevitability of life extension, and consider possible solutions to the growing issues of social and ethical implications and concerns. Edited by the internationally acclaimed founders of the philosophy and social movement of transhumanism, The Transhumanist Reader is an indispensable guide to our current state of knowledge of the quest to expand the frontiers of human nature.

8502.32 рублей

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Lorenzo Pinna A. Protein Kinase CK2

Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

16012.26 рублей

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Mohammad Alhawary T. Modern Standard Arabic Grammar. A Learner's Guide

Modern Standard Arabic Grammar is comprehensive guide that introduces readers to the basic structure and grammar of the Arabic language. Its features include: Comprehensive coverage of Arabic grammar and structure in current standard use (MSA), from entry level to advanced proficiency Balanced treatment of the phonological, syntactic, and morphological rules of the Arabic language An intuitive presentation of grammar rules and structures, in order of frequency and functional use Straightforward explanations with minimum linguistic jargon and terminology, explaining the key issues Packed throughout with symbols, tables, diagrams, and illustrative examples, this book is essential reading for anyone in the early years of studying the language.

2139.84 рублей

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Rahman Mohammad Shafiur Handbook of Food Process Design, 2 Volume Set

In the 21st Century, processing food is no longer a simple or straightforward matter. Ongoing advances in manufacturing have placed new demands on the design and methodology of food processes. A highly interdisciplinary science, food process design draws upon the principles of chemical and mechanical engineering, microbiology, chemistry, nutrition and economics, and is of central importance to the food industry. Process design is the core of food engineering, and is concerned at its root with taking new concepts in food design and developing them through production and eventual consumption. Handbook of Food Process Design is a major new 2-volume work aimed at food engineers and the wider food industry. Comprising 46 original chapters written by a host of leading international food scientists, engineers, academics and systems specialists, the book has been developed to be the most comprehensive guide to food process design ever published. Starting from first principles, the book provides a complete account of food process designs, including heating and cooling, pasteurization, sterilization, refrigeration, drying, crystallization, extrusion, and separation. Mechanical operations including mixing, agitation, size reduction, extraction and leaching processes are fully documented. Novel process designs such as irradiation, high-pressure processing, ultrasound, ohmic heating and pulsed UV-light are also presented. Food packaging processes are considered, and chapters on food quality, safety and commercial imperatives portray the role process design in the broader context of food production and consumption.

43680.24 рублей

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Zygmunt Bauman Of God and Man

In this engaging dialogue, Zygmunt Bauman, sociologist and philosopher, and Stanislaw Obirek, theologian and cultural historian, explore the place of spirituality and religion in the world today and in the everyday lives of individuals. Their conversation ranges from the plight of monotheistic religions cast onto a polytheistic world stage to the nature of religious experience and its impact on human worldviews and life strategies; from Messianic and Promethean ideas of redemption and salvation to the possibility and prospects of inter-religious dialogue and the factors standing in its way. While starting from different places, Bauman and Obirek are driven by the same concern to reconcile the multiplicity of religions with the oneness of humanity, and to do so in a way that avoids the trap of adhering to a single truth, bearing witness instead to the multiplicity of human truths and the diversity of cultures and faiths. For everything creative in human existence has its roots in human diversity; it is not human diversity that turns brother against brother but the refusal of it. The fundamental condition of peace, solidarity and benevolent cooperation among human beings is a willingness to accept that there is a multiplicity of ways of being human, and a willingness to accept the model of coexistence that this multiplicity requires.

4870.24 рублей

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Patrick Millot Designing Human-machine Cooperation Systems

This book, on the ergonomics of human−machine systems, is aimed at engineers specializing in informatics, automation, production or robotics, who are faced with a significant dilemma during the conception of human−machine systems. On the one hand, the human operator guarantees the reliability of the system and has been known to salvage numerous critical situations through an ability to reason in unplanned, imprecise and uncertain situations; on the other hand, the human operator can be unpredictable and create disturbances in the automated system. The first part of the book is dedicated to the methods of human-centered design, from three different points of view, the various chapters focusing on models developed by human engineers and functional models to explain human behavior in their environment, models of cognitive psychology and models in the domain of automobile driving. Part 2 develops the methods of evaluation of the human−machine systems, looking at the evaluation of the activity of the human operator at work and human error analysis methods. Finally, Part 3 is dedicated to human−machine cooperation, where the authors show that a cooperative agent comprises a know-how and a so-called know-how-to-cooperate and show the way to design and evaluate that cooperation in real industrial contexts.

14321.19 рублей

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Mohammad Shahidehpour Handbook of Electrical Power System Dynamics. Modeling, Stability, and Control

This book aims to provide insights on new trends in power systems operation and control and to present, in detail, analysis methods of the power system behavior (mainly its dynamics) as well as the mathematical models for the main components of power plants and the control systems implemented in dispatch centers. Particularly, evaluation methods for rotor angle stability and voltage stability as well as control mechanism of the frequency and voltage are described. Illustrative examples and graphical representations help readers across many disciplines acquire ample knowledge on the respective subjects.

11997.76 рублей

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Patrizia Lombardi Future Challenges in Evaluating and Managing Sustainable Development in the Built Environment

Future Challenges in Sustainable Development within the Built Environment stimulates and reinterprets the demands of Responsible and Sustainable Development in the Built Environment for future action and development. It examines the methods of evaluation, the use of technology, the creation of new models and the role of human factors for examining and developing the subject over the next twenty years.

11247.23 рублей

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Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

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