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Antimicrobial resistance is arguably the greatest threat to worldwide human health. This book evaluates the roles of human water use, treatment and conservation in the development and spread of antimicrobial resistance. Designed as a companion volume to Antimicrobial Resistance in the Environment (Wiley-Blackwell, 2012), this book is a multi-disciplinary synthesis of topics related to antimicrobial resistance and wastewater treatment processes. Antimicrobial Resistance in Wastewater Treatment Processes assembles detailed discussions written by many of the world's best-known experts in microbiology, civil engineering, chemistry, environmental science, public health and related fields. The book presents a collection of subjects that includes: Current knowledge of the role of the environment in development and spread of antimicrobial resistance Chemical analysis of antibiotics in environmental samples Molecular methods for analysis of antimicrobial resistance genes Advanced wastewater treatment processes and antimicrobial resistance effects Public perception of risk related to health consequences of antimicrobial resistance Public health implications of antimicrobial resistance with focus on wastewater treatment processes Antimicrobial resistance has gained a foothold in the global consciousness as a serious public health threat. There is a much greater appreciation for the role of the environment in the dissemination of antimicrobial resistance and the effects of pollutants that can potentially promote development of resistance in bacteria. Contaminants released from wastewater treatment plants are a concern. In Antimicrobial Resistance in Wastewater Treatment Processes, readers will be guided through examinations of the current science related to this important health issue.
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Examines effects of the environmental distribution of antimicrobial resistance genes on human health and the ecosystem Resistance genes are everywhere in nature—in pathogens, commensals, and environmental microorganisms. This contributed work shows how the environment plays a pivotal role in the development of antimicrobial resistance traits in bacteria and the distribution of resistant microbial species, resistant genetic material, and antibiotic compounds. Readers will discover the impact of the distribution in the environment of antimicrobial resistance genes and antibiotics on both the ecosystem and human and animal health. Antimicrobial Resistance in the Environment is divided into four parts: Part I, Sources, including ecological and clinical consequences of antibiotic resistance by environmental microbes Part II, Fate, including strategies to assess and minimize the biological risk of antibiotic resistance in the environment Part III, Antimicrobial Substances and Resistance, including antibiotics in the aquatic environment Part IV, Effects and Risks, including the effect of antimicrobials used for non-human purposes on human health Recognizing the intricate links among overlapping complex systems, this book examines antimicrobial resistance using a comprehensive ecosystem approach. Moreover, the book's multidisciplinary framework applies principles of microbiology, environmental toxicology, and chemistry to assess the human and ecological risks associated with exposure to antibiotics or antibiotic resistance genes that are environmental contaminants. Each chapter has been written by one or more leading researchers in such fields as microbiology, environmental science, ecology, and toxicology. Comprehensive reference lists at the end of all chapters serve as a gateway to the primary research in the field. Presenting and analyzing the latest findings in a field of growing importance to human and environmental health, this text offers readers new insights into the role of the environment in antimicrobial resistance development, the dissemination of antimicrobial resistant genetic elements, and the transport of antibiotic resistance genes and antibiotics.
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A Companion to South Asia in the Past provides the definitive overview of research and knowledge about South Asia’s past, from the Pleistocene to the historic era in India, Pakistan, Sri Lanka, Bangladesh and Nepal, provided by a truly global team of experts. The most comprehensive and detailed scholarly treatment of South Asian archaeology and biological anthropology, providing ground-breaking new ideas and future challenges Provides an in-depth and broad view of the current state of knowledge about South Asia’s past, from the Pleistocene to the historic era in India, Pakistan, Sri Lanka, Bangladesh and Nepal A comprehensive treatment of research in a crucial region for human evolution and biocultural adaptation A global team of scholars together present a varied set of perspectives on South Asian pre- and proto-history
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This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in various antibacterial agents and explanations of how resistances to those develop. Methods for counteracting resistance development in bacteria are discussed as well.
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Coal Geology, second edition, offers a thoroughly revised and updated edition of this popular book which provides a comprehensive overview of the field of coal geology. Coal Geology covers all aspects of coal geology in one volume, bridging the gap between the academic aspects and the practical role of geology in the coal industry. The object of the book is to provide the reader with a with a description of the origins of coal together with the physical and chemical properties of coal and coal petrology before proceeding to cover all areas of coal exploration, production and use. Bridges the gap between academic aspects of coal geology and the practical role of geology in the coal industry Examines historical and stratigraphical geology, together with mining, environmental issues, geophysics and hydrogeology and the marketing of coal Defines worldwide coal resource classifications and methods of calculation Addresses the alternative uses of coal as a source of energy, together with the environmental implications of coal usage Includes improved illustrations including a colour section Offers a global approach covering expanding fields in America, China and India The truly global approach, drawn from the international experiences of the author, recognizes the growing role of coal use in emerging markets. With fully revised coverage of the latest modelling techniques, environmental legislation, equipment and recording methods, the second edition offers a truly invaluable resource for anyone studying, researching or working in the field of coal geology, geotechnical and mining engineering and environmental science.
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Cities in Relations advances a novel way of thinking about urban transformation by focusing on transnational relations in the least developed countries. Examines the last 20 years of urban development in Hanoi, Vietnam, and in Ouagadougou, Burkina Faso Considers the ways in which a city’s relationships with other places influences its urban development Provides fresh ideas for comparative urban studies that move beyond discussions of economic and policy factors Offers a clear and concise narrative accompanied by more than 45 photos and maps
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A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.
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In its first edition, Practice Development in Nursing made an important contribution to understanding practice development and its core components. Now fully updated to take into account the many developments in the field, the second edition continues to fill an important gap in the market for an accessible, practical text on what remains a key issue for all members of the healthcare team globally. Practice Development in Nursing and Healthcare explores the basis of practice development and its aims, implementation and impact on healthcare, to enable readers to be confident in their approaches to practice development. It is aimed at healthcare professionals in a variety of roles (for example clinical practice, education, research and quality improvement) and students, as well as those with a primary practice development role, in order to enable them to effectively and knowledgeably develop practice and the practice of others. Key features: New updated edition of a seminal text in the field, including significant new material Relevance to the entire healthcare team Accessible and practical in style, with case studies, scenarios and examples throughout Edited by and with contributions from experts in the field Fully updated to include the latest research Supported by a strong evidence base
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Leadership development is a planned effort that enhances the learner's capacity to lead people. Building on the success of the first edition, Linkage conducted a study of over 300 top organizations and their needs in organizational change and leadership development that identifies approaches to leadership development that have proven to be successful. The work offers practical «how-to» instructions developing leaders and engaging in leadership development. It provides current in-depth models, assessments, tools, and other instruments that can be used for immediate application within a variety of organizations.
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An updated edition of the definitive handbook on the physical basis for learning for professionals involved in education and child development, written by the respected author of acclaimed titles in the field. A comprehensive overview of the relationship between neuromotor maturity and physical development on learning outcomes and behaviour in childhood and later life Explores why early reflexes are important, their functions in early development, their effects on learning and behavior if retained, and the possible effects on other aspects of development Brings together a specialist body of knowledge and makes it accessible to anyone involved in treating the symptoms of specific learning difficulties and emotional problems. Includes new information on the role of the vestibular system in anxiety and agoraphobia, a new chapter of case studies, and an Epilogue placing the INPP Method in a broader scientific context
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A thorough treatment of product and systems development in terms of value to all stakeholders Product and Systems Development compiles more than twenty years of research and practice from a value perspective, from vision and marketing to design, manufacturing, delivery, operations, and maintenance. It defines stakeholder value and identifies specific stakeholders in the product and system development process; covers best practices in development; and examines systems engineering, current industry views, and the life cycle of a value stream. Featuring appendices written by professionals in the field on topics such as Design Structure Matrices, Lean Enablers for systems engineering, and MDAO and simulations, this indispensable guide: Explains why stakeholders' values can hold the key to fulfillment or defeat of the developer's vision Emphasizes the succession of value-contributing practices and tools that form a framework for development success Integrates the technical, productivity, and customer/end-user elements in product and system development Uses more than 100 tables and figures to illustrate the above processes, as well as corollary elements of risk, failure analysis, and fault-tolerant design Includes numerous case studies and links to online material Product and Systems Development is an excellent coursebook for senior and graduate students in aerospace, mechanical, civil, electrical, and material engineering, as well as management science and engineering. It is also a useful reference for practicing engineers in a variety of technology-based industries.
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Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.
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This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
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A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
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This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
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Since the publication of her landmark book In a Different Voice, Carol Gilligan has transformed the way we think about women and men and the relations between them. It was ‘the little book that started a revolution’, and with more than 800,000 copies in print it has become one of the most widely read and influential books ever written on gender and human development. In her new book Joining the Resistance Carol Gilligan reflects on the evolution of her thinking and shows how her key ideas were interwoven with her own life experiences. Her work began with the question of voice: who is speaking to whom, in what body, telling what stories about which relationships? By listening carefully she heard a voice that had been held in silence, and in the process realized the extent to which we – both women and men – had been telling false stories about ourselves. In her subsequent work Gilligan found that adolescent girls resisted pressures to disengage themselves from their honest voices, and by joining their resistance she opened the way for the development of a more humane way of thinking about personal and political relationships. For the central conviction of her work today – and the central thesis of this book – is that the requisites for love and the requisites for citizenship in a democratic society are one and the same. Both voice and the desire to live in relationships inherent in our human nature, together with the capacity to resist false authority. Combining autobiographical reflection with an analysis of key questions about gender and human development, this timely and highly readable book by one of America’s greatest contemporary thinkers will appeal to a wide readership.
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Треклист: 1. DVD 1 Ouvertura (ERSTER AKT)2. "La mia Dorabella" (ERSTER AKT)3. "Fuor la spada" (ERSTER AKT)4. E la fede delle femmine (ERSTER AKT)5. Scocchiere di poeti! (ERSTER AKT)6. "Una bella serenata" (ERSTER AKT)7. "Ah, guarda, sorella" (ERSTER AKT)8. "Mi par che stamattina" (ERSTER AKT)9. Vorrei dir, e cor non ho (ERSTER AKT)10. Stelle! Per carita, signor Alfonso, non ci fate morir (ERSTER AKT)11. "Sento, oh Dio, che questo piede" (ERSTER AKT)12. "La commedia # graziosa" (ERSTER AKT)13. Bella vita militar! (ERSTER AKT)14. Non v