mahmood ahmad tahira shamim and laila sumreen antidiabetic activity of medicinal plants from cholistan desert

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Denise Bohrer Sources of Contamination in Medicinal Products and Medical Devices

The first one-volume guide to sources of contamination in pharmaceuticals and medical devices Most books dealing with contaminants in medicinal products often focus on analytical methods for detecting nonspecific impurities. Key to the work of the pharmaceutical chemist, this unique reference helps identify the sources of contamination in medicinal and pharmaceutical products and medical devices. Divided into three parts, Sources of Contamination in Medicinal Products and Medical Devices covers chemical, microbiological, and physical (particulate matter) contamination, including those originating from sterilization procedures. As compelling as a medical documentary, the book sheds light on how impurities and contaminants can enter the human body transported via a specific product or treatment. Focusing on only those medicinal products and medical devices that may lead to exposure to contaminants harmful to human health, the book offers a comprehensive, systematic look at the entire universe of medical contamination: Chemical contaminants including residual solvents, catalyst residuals, and genotoxic impurities in active pharmaceutical ingredients (APIs) Diagnostic imaging agents (i.e., radiopharmaceuticals and contrast agents) Microbiological and endotoxin contamination involving single and multiple dose products, medical devices, and biofilms Contamination from sterilization procedures, residuals from radiation sterilization, ionizing radiation on packaging materials and medical devices Medicinal gases and volatile anesthetics Biopharmaceuticals including recombinant DNA technology products Extractables and leachables from containers made of glass, plastics, and metal Each section of the book contains information on what contaminants could be expected in a particular product, and how they were generated and reached that product. With up-to-date regulatory guidelines for determining contamination, as well as methods for assessing, quantifying, avoiding and removing contaminants, Sources of Contamination in Medicinal Products and Medical Devices is essential to fully understanding the specific threats that undermine the safety of medicines and medical devices.

12644.28 рублей

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Shahid Ul-Islam Plant-Based Natural Products. Derivatives and Applications

Intense research has been started all around the world in the past few decades to exploit different agents from natural products as eco-friendly alternative to synthetic and toxic chemicals. Natural products and their derivatives have received increasing attention for their use in many everyday applications ranging from food, medicine, textiles, and healthcare.This new book presents significant research advances about the use of natural products, mainly plant colorants, bioactive compounds and other plant extracts in the textile coloration, food, bioremediation and environmental applications. There are total eight chapters contributed by leading researchers covering the topics such as potential resurgence of natural dyes in applied fields, natural colorants from indigoid plants, phytochemistry of dye yielding plants, irradiation as novel pretreatment methods, dyeing studies with henna plant, phytoremediation of arsenic, and synthesis of curcumin complexes for medicinal and other industrial uses.

14622.12 рублей

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Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry

The book «Drug Selectivity – An Evolving Concept in Medicinal Chemistry» provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

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Hugo Kubinyi Microwaves in Organic and Medicinal Chemistry

Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with an additional volume. As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation and equipment. The main part of the book then goes on to systematically survey the complete range of published microwave-assisted synthesis methods from their beginnings in the 1990s to mid-2011, drawing on data from more than 5,000 reports and publications. Throughout, the focus is on those reactions, reagents and reaction conditions that work, and that are the most relevant for medicinal and natural products chemistry. A much expanded section is devoted to combinatorial, highthroughput and flow chemistry methods.

18371.19 рублей

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Arturo Pardo-Giménez Edible and Medicinal Mushrooms. Technology and Applications

Comprehensive and timely, Edible and Medicinal Mushrooms: Technology and Applications provides the most up to date information on the various edible mushrooms on the market. Compiling knowledge on their production, application and nutritional effects, chapters are dedicated to the cultivation of major species such as Agaricus bisporus, Pleurotus ostreatus, Agaricus subrufescens, Lentinula edodes, Ganoderma lucidum and others. With contributions from top researchers from around the world, topics covered include: Biodiversity and biotechnological applications Cultivation technologies Control of pests and diseases Current market overview Bioactive mechanisms of mushrooms Medicinal and nutritional properties Extensively illustrated with over 200 images, this is the perfect resource for researchers and professionals in the mushroom industry, food scientists and nutritionists, as well as academics and students of biology, agronomy, nutrition and medicine.

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Diane Cook J. Activity Learning. Discovering, Recognizing, and Predicting Human Behavior from Sensor Data

Defines the notion of an activity model learned from sensor data and presents key algorithms that form the core of the field Activity Learning: Discovering, Recognizing and Predicting Human Behavior from Sensor Data provides an in-depth look at computational approaches to activity learning from sensor data. Each chapter is constructed to provide practical, step-by-step information on how to analyze and process sensor data. The book discusses techniques for activity learning that include the following: Discovering activity patterns that emerge from behavior-based sensor data Recognizing occurrences of predefined or discovered activities in real time Predicting the occurrences of activities The techniques covered can be applied to numerous fields, including security, telecommunications, healthcare, smart grids, and home automation. An online companion site enables readers to experiment with the techniques described in the book, and to adapt or enhance the techniques for their own use. With an emphasis on computational approaches, Activity Learning: Discovering, Recognizing, and Predicting Human Behavior from Sensor Data provides graduate students and researchers with an algorithmic perspective to activity learning.

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Julie Laity J Deserts and Desert Environments

Taking a global perspective, this book provides a concise overview of drylands, including their physical, biological, temporal, and human components. Examines the physical systems occurring in desert environments, including climate, hydrology, past and present lakes, weathering, hillslopes, geomorphic surfaces, water as a geomorphic agent, and aeolian processes Offers an accessible introduction to the physical, biological, temporal, and human components of drylands Investigates the nature, environmental requirements, and essential geomorphic roles of plants and animals in this stressful biological environment Highlights the impact of human population growth on climate, desertification, water resources, and dust storm activity Includes an examination of surface/atmosphere interactions and the impact of ENSO events.

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Zhang Wei Green Techniques for Organic Synthesis and Medicinal Chemistry

An updated overview of the rapidly developing field of green engineering techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

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100 Bugs to Fold and Fly

A creative activity book which allows children to make a variety of bug themed paper airplanes from the fantastically designed pages. Follow the instructions and fold the pages to create an array of bugs, from dragonflies and butterflies to grasshoppers and beetles.

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Parvaiz Ahmad Plant-Environment Interaction. Responses and Approaches to Mitigate Stress

The increase in global population, urbanization and industrialization is resulting in the conversion of cultivated land into wasteland. Providing food from these limited resources to an ever-increasing population is one of the biggest challenges that present agriculturalists and plant scientists are facing. Environmental stresses make this situation even graver. Plants on which mankind is directly or indirectly dependent exhibit various mechanisms for their survival. Adaptability of the plants to changing environment is a matter of concern for plant biologists trying to reach the goal of food security. Despite the induction of several tolerance mechanisms, sensitive plants often fail to withstand these environmental extremes. Using new technological approaches has become essential and imperative. Plant-Environment Interaction: Responses and Approaches to Mitigate Stress throws light on the changing environment and the sustainability of plants under these conditions. It contains the most up-to-date research and comprehensive detailed discussions in plant physiology, climate change, agronomy and forestry, sometimes from a molecular point of view, to convey in-depth understanding of the effects of environmental stress in plants, their responses to the environment, how to mitigate the negative effects and improve yield under stress. This edited volume is written by expert plant biologists from around the world, providing invaluable knowledge to graduate and undergraduate students in plant biochemistry, food chemistry, plant physiology, molecular biology, plant biotechnology, and environmental sciences. This book updates scientists and researchers with the very latest information and sustainable methods used for stress tolerance, which will also be of considerable interest to plant based companies and institutions concerned with the campaign of food security.

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Karen Lackey Medicinal Chemistry Approaches to Personalized Medicine

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of «personalized drugs» are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more

14696.81 рублей

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Van Nguyen Tang Recovering Bioactive Compounds from Agricultural Wastes

A guide to the extraction, isolation and purification of bioactive compounds from agricultural wastes, and their applications Recovering Bioactive Compounds from Agricultural Wastes offers a guide to the many uses of agricultural wastes from the production of major food types including tea, coffee, cacao, cashew, fruit and vegetables, wine, edible oils, sugar, starch and more. Written by a noted expert in the field, the text explores the various methods for extraction, isolation and purification of bioactive compounds from agricultural wastes. The author also makes recommendations concerning the most effective applications of bioactive compounds and discusses the economics and market for recovered bioactive compounds. Recent studies reveal that bioactive compounds have been directly linked to biological activity such as antioxidant, anticancer, antidiabetic, anti-cardiovascular capacities, etc. In particular, agricultural wastes are considered as potential and inexpensive sources of bioactive compounds. Recovering Bioactive Compounds from Agricultural Wastes fills a gap in the literature by providing a text that explores this important topic and examines the: Sustainability of waste management and shows how to extract, isolate and purify bioactive compounds from agricultural wastes, and their most effective application Wide range of agricultural food produce that can be processed and the special techniques used for recovering the bioactive compounds from these sources Health applications of bioactive compounds that have been directly linked to pharmacological activities including antioxidant, anticancer, and more Designed for use by researchers and producers in the agriculture, pharmaceuticals and nutraceuticals, Recovering Bioactive Compounds from Agricultural Wastes contains the knowledge, history and definition, classification and synthesis, and extraction techniques of bioactive compounds.

11247.23 рублей

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Valdir Cechinel-Filho Plant Bioactives and Drug Discovery. Principles, Practice, and Perspectives

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

14789.98 рублей

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Li-He Zhang Medicinal Chemistry of Nucleic Acids

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

12818.01 рублей

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Werngard Czechtizky Small Molecule Medicinal Chemistry. Strategies and Technologies

Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting

11247.23 рублей

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I Love Unicorns Puffy Sticker Activity Book

This unicorn themed activity book is packed with things to do, from colouring and doodling activities through to unicorn press outs and a sheet of puffy stickers! At the back of this fun filled activity book, there are card pages with press-outs to colour and decorate.

989 рублей

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Parvaiz Ahmad Water Stress and Crop Plants. A Sustainable Approach, 2 Volume Set

Plants are subjected to a variety of abiotic stresses such as drought, temperature, salinity, air pollution, heavy metals, UV radiations, etc. To survive under these harsh conditions plants are equipped with different resistance mechanisms which vary from species to species. Due to the environmental fluctuations agricultural and horticultural crops are often exposed to different environmental stresses leading to decreased yield and problems in the growth and development of the crops. Drought stress has been found to decrease the yield to an alarming rate of some important crops throughout the globe. During last few decades, lots of physiological and molecular works have been conducted under water stress in crop plants. Water Stress and Crop Plants: A Sustainable Approach presents an up-to-date in-depth coverage of drought and flooding stress in plants, including the types, causes and consequences on plant growth and development. It discusses the physiobiochemical, molecular and omic approaches, and responses of crop plants towards water stress. Topics include nutritional stress, oxidative stress, hormonal regulation, transgenic approaches, mitigation of water stress, approaches to sustainability, and modern tools and techniques to alleviate the water stress on crop yields. This practical book offers pragmatic guidance for scientists and researchers in plant biology, and agribusinesses and biotechnology companies dealing with agronomy and environment, to mitigate the negative effects of stress and improve yield under stress. The broad coverage also makes this a valuable guide enabling students to understand the physiological, biochemical, and molecular mechanisms of environmental stress in plants.

26634.82 рублей

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The first one-volume guide to sources of contamination in pharmaceuticals and medical devices Most books dealing with contaminants in medicinal products often focus on analytical methods for detecting nonspecific impurities. Key to the work of the pharmaceutical chemist, this unique reference helps identify the sources of contamination in medicinal and pharmaceutical products and medical devices. Divided into three parts, Sources of Contamination in Medicinal Products and Medical Devices covers chemical, microbiological, and physical (particulate matter) contamination, including those originating from sterilization procedures. As compelling as a medical documentary, the book sheds light on how impurities and contaminants can enter the human body transported via a specific product or treatment. Focusing on only those medicinal products and medical devices that may lead to exposure to contaminants harmful to human health, the book offers a comprehensive, systematic look at the entire universe of medical contamination: Chemical contaminants including residual solvents, catalyst residuals, and genotoxic impurities in active pharmaceutical ingredients (APIs) Diagnostic imaging agents (i.e., radiopharmaceuticals and contrast agents) Microbiological and endotoxin contamination involving single and multiple dose products, medical devices, and biofilms Contamination from sterilization procedures, residuals from radiation sterilization, ionizing radiation on packaging materials and medical devices Medicinal gases and volatile anesthetics Biopharmaceuticals including recombinant DNA technology products Extractables and leachables from containers made of glass, plastics, and metal Each section of the book contains information on what contaminants could be expected in a particular product, and how they were generated and reached that product. With up-to-date regulatory guidelines for determining contamination, as well as methods for assessing, quantifying, avoiding and removing contaminants, Sources of Contamination in Medicinal Products and Medical Devices is essential to fully understanding the specific threats that undermine the safety of medicines and medical devices.

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