irshad ahmad invitro induction of mutation in potato cultivars

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Wang Yongjun Gene Discovery for Disease Models

This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).

11724.7 рублей

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Chan Tze Fun Applied Intelligent Control of Induction Motor Drives

Induction motors are the most important workhorses in industry. They are mostly used as constant-speed drives when fed from a voltage source of fixed frequency. Advent of advanced power electronic converters and powerful digital signal processors, however, has made possible the development of high performance, adjustable speed AC motor drives. This book aims to explore new areas of induction motor control based on artificial intelligence (AI) techniques in order to make the controller less sensitive to parameter changes. Selected AI techniques are applied for different induction motor control strategies. The book presents a practical computer simulation model of the induction motor that could be used for studying various induction motor drive operations. The control strategies explored include expert-system-based acceleration control, hybrid-fuzzy/PI two-stage control, neural-network-based direct self control, and genetic algorithm based extended Kalman filter for rotor speed estimation. There are also chapters on neural-network-based parameter estimation, genetic-algorithm-based optimized random PWM strategy, and experimental investigations. A chapter is provided as a primer for readers to get started with simulation studies on various AI techniques. Presents major artificial intelligence techniques to induction motor drives Uses a practical simulation approach to get interested readers started on drive development Authored by experienced scientists with over 20 years of experience in the field Provides numerous examples and the latest research results Simulation programs available from the book's Companion Website This book will be invaluable to graduate students and research engineers who specialize in electric motor drives, electric vehicles, and electric ship propulsion. Graduate students in intelligent control, applied electric motion, and energy, as well as engineers in industrial electronics, automation, and electrical transportation, will also find this book helpful. Simulation materials available for download at www.wiley.com/go/chanmotor

13027.44 рублей

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Irfan Ahmad Prosthodontics at a Glance

Prosthodontics at a Glance is a title in the popular At A Glance series and focuses on prosthodontics from diagnostics through treatment to post-operative maintenance. It is an ideal companion for all students of dentistry, clinicians and members of the dental team with an interest in prosthodontics.

4137.49 рублей

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Jean Alacoque Claude Direct Eigen Control for Induction Machines and Synchronous Motors

Clear presentation of a new control process applied to induction machine (IM), surface mounted permanent magnet synchronous motor (SMPM-SM) and interior permanent magnet synchronous motor (IPM-SM) Direct Eigen Control for Induction Machines and Synchronous Motors provides a clear and consise explanation of a new method in alternating current (AC) motor control. Unlike similar books on the market, it does not present various control algorithms for each type of AC motor but explains one method designed to control all AC motor types: Induction Machine (IM), Surface Mounted Permanent Magnet Synchronous Motor (SMPM-SM) (i.e. Brushless) and Interior Permanent Magnet Synchronous Motor (IPM-SM). This totally new control method can be used not only for AC motor control but also to control input filter current and voltage of an inverter feeding an AC motor. Accessible and clear, describes a new fast type of motor control applied to induction machine (IM), surface mounted permanent magnet synchronous motor (SM-PMSM) and interior permanent magnet synchronous motor (I-PMSM) with various examples Summarizes a method that supersedes the two known direct control solutions – Direct Self Control and Direct Torque Control – to be used for AC motor control and to control input filter current and voltage of an inverter feeding an AC motor Presents comprehensive simulations that are easy for the reader to reproduce on a computer. A control program is hosted on a companion website This book is straight-forward with clear mathematical description. It presents simulations in a way that is easy to understand and to reproduce on a computer, whilst omitting details of practical hardware implementation of control, in order for the main theory to take focus. The book remains concise by leaving out description of sensorless controls for all motor types. The sections on “Control Process”, “Real Time Implementation” and “Kalman Filter Observer and Prediction” in the introductory chapters explain how to practically implement, in real time, the discretized control with all three types of AC motors. In order, this book describes induction machine, SMPM-SM, IPM-SM, and, application to LC filter limitations. The appendixes present: PWM vector calculations; transfer matrix calculation; transfer matrix inversion; Eigen state space vector calculation; and, transition and command matrix calculation. Essential reading for Researchers in the field of drive control; graduate and post-graduate students studying electric machines; electric engineers in the field of railways, electric cars, plane surface control, military applications. The approach is also valuable for Engineers in the field of machine tools, robots and rolling mills.

11247.23 рублей

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Alexey Kondrashov S. Crumbling Genome. The Impact of Deleterious Mutations on Humans

A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre?]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.

7494.6 рублей

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Ralph Rapley Molecular Analysis and Genome Discovery

Molecular Analysis and Genome Discovery, Second Edition is a completely revised and updated new edition of this successful book. The text provides a comprehensive overview of recent developments in the fast moving field of molecular based diagnostics of disease markers. Key concepts and applications are provided alongside practical information on current techniques currently being researched and developed. Each chapter offers an up-to-date analysis of the subject encompassing the very latest technology platforms and is an essential reference for researchers in the field looking for an up-to-date overview of the subject. The book will also be an indispensable resource for those working in the biotechnology and pharmaceutical industries. New for this edition: chapters on Genotyping through Mutation Detection; Differential Gene Expression; Haplotyping and Molecular Profiling.

11993.49 рублей

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Bo Peng Forward-Time Population Genetics Simulations. Methods, Implementation, and Applications

The only book available in the area of forward-time population genetics simulations—applicable to both biomedical and evolutionary studies The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies. Forward-Time Population Genetics Simulations presents both new and commonly used methods, and introduces simuPOP, a powerful and flexible new program that can be used to simulate arbitrary evolutionary processes with unique features like customized chromosome types, arbitrary nonrandom mating schemes, virtual subpopulations, information fields, and Python operators. The book begins with an overview of important concepts and models, then goes on to show how simuPOP can simulate a number of standard population genetics models—with the goal of demonstrating the impact of genetic factors such as mutation, selection, and recombination on standard Wright-Fisher models. The rest of the book is devoted to applications of forward-time simulations in various research topics. Forward-Time Population Genetics Simulations includes: An overview of currently available forward-time simulation methods, their advantages, and shortcomings An overview and evaluation of currently available software A simuPOP tutorial Applications in population genetics Applications in genetic epidemiology, statistical genetics, and mapping complex human diseases The only book of its kind in the field today, Forward-Time Population Genetics Simulations will appeal to researchers and students of population and statistical genetics.

8322.67 рублей

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Pragati Kaushal Tropical Roots and Tubers. Production, Processing and Technology

Roots and tubers are considered as the most important food crops after cereals and contribute significantly to sustainable development, income generation and food security especially in the tropical regions. The perishable nature of roots and tubers demands appropriate storage conditions at different stages starting from farmers to its final consumers. Because of their highly perishable nature, search for efficient and better methods of preservation/processing have been continuing alongside the developments in different arena. This book covers the processing and technological aspects of root and tuber foods, detailing the production and processing of roots and tubers such as taro, cassava, sweet potato, yam and elephant foot yam. Featuring chapters on anatomy, taxonomy and physiology, molecular and biochemical characterization, GAP, GMP, HACCP, Storage techniques, as well as the latest technological interventions in Taro, Cassava, Sweet potato, yam and Elephant foot Yam.

15366.24 рублей

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Ian Culbert Current Signature Analysis for Condition Monitoring of Cage Induction Motors. Industrial Application and Case Histories

Provides coverage of Motor Current Signature Analysis (MCSA) for cage induction motors This book is primarily for industrial engineers. It has 13 chapters and contains a unique data base of 50 industrial case histories on the application of MCSA to diagnose broken rotor bars or unacceptable levels of airgap eccentricity in cage induction motors with ratings from 127 kW (170 H.P.) up to 10,160 kW (13,620 H.P.). There are also unsuccessful case histories, which is another unique feature of the book. The case studies also illustrate the effects of mechanical load dynamics downstream of the motor on the interpretation of current signatures. A number of cases are presented where abnormal operation of the driven load was diagnosed. Chapter 13 presents a critical appraisal of MCSA including successes, failures and lessons learned via industrial case histories. The case histories are presented in a step by step format, with predictions and outcomes supported by current spectra and photographic evidence to confirm a correct or incorrect diagnosis The case histories are presented in detail so readers fully understand the diagnosis The authors have 108 years of combined experience in the installation, maintenance, repair, design, manufacture, operation and condition monitoring of SCIMs There are 10 questions at the end of chapters 1 to 12 and answers can be obtained via the publisher Current Signature Analysis for Condition Monitoring of Cage Induction Motors serves as a reference for professional engineers, head electricians and technicians working with induction motors. To obtain the solutions manual for this book, please send an email to [email protected] William T. Thomson is Director and Consultant with EM Diagnostics Ltd, in Scotland. Prof. Thomson received a BSc (Hons) in Electrical Engineering in 1973 and an MSc in 1977 from the University of Strathclyde. He has published 72 papers on condition monitoring of induction motors in a variety of engineering journals such as IEEE Transactions (USA), IEE Proceedings (UK), and also at numerous International IEEE and IEE conferences. He is a senior member of the IEEE, a fellow of the IEE (IET) in the UK and a Chartered Professional Engineer registered in the UK. Ian Culbert was a Rotating Machines Specialist at Iris Power Qualitrol since April 2002 until his very untimely death on 8th September, 2015. At this company he provided consulting services to customers, assisted in product development, trained sales and field service staff and reviewed stator winding partial discharge reports. He has co-authored two books on electrical machine insulation design, evaluation, aging, testing and repair and was principal author of a number of Electric Power Research Institute reports on motor repair. Ian was a Registered Professional Engineer in the Province of Ontario, Canada and a Senior Member of IEEE.

10497.42 рублей

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Perumal Narayanasamy Microbial Plant Pathogens. Detection and Management in Seeds and Propagules

Healthy seeds and propagules are the basic requirement for producing good grains, fruits and vegetables needed for human survival and perpetuation. Dispersal of microbial plant pathogens via seeds and propagules has assumed more importance than other modes of dispersal, as infected seeds and propagules have the potential to become the primary sources of carrying pathogen inoculum for subsequent crops. Several diseases transmitted through seeds and propagules have been shown to have the potential to damage economies as a result of huge quantitative and qualitative losses in numerous crops. Hence, it is essential to rapidly detect, identify and differentiate the microbial plant pathogens present in seeds and propagules precisely and reliably, using sensitive techniques. Microbial Plant Pathogens: Detection and Management in Seeds and Propagules provides a comprehensive resource on seed-borne and propagule-borne pathogens. Information on the biology of microbial pathogens, including genetic diversity, infection process and survival mechanisms of pathogens and epidemiology of diseases caused by them, are discussed critically and in detail to highlight weak links in the life cycles of the pathogens. Development of effective disease management systems, based on the principles of exclusion and eradication of pathogens and immunization of crop plants to enhance the levels of resistance of cultivars to diseases, has been effective to keep the pathogens at bay. The need for production of disease-free seeds/propagules has been emphasized to prevent the carryover of the inoculum to the next crop or introduction of the pathogens to other locations. Effectiveness of adopting simple cultural practices and development of cultivars resistant to diseases through traditional breeding methods or biotechnological approach have resulted in reducing the pathogen inoculum and disease incidence. Although application of different chemicals may reduce the disease incidence effectively, biological management of crop diseases, employing potential biological control agents have to be preferred to preserve the agroecosystems. Greater efforts have to be made to integrate compatible strategies to enhance the effectiveness of diseases management systems. Protocols appended at the end of relevant chapters form a unique feature of this book to enable the researchers to fine-tune their projects. This 2 volume set provides comprehensive and updated information about the economically-important groups of microbial plant pathogens carried by seed and propagules. Graduate students, researchers and teachers of plant pathology, plant protection, microbiology, plant breeding and genetics, agriculture and horticulture, as well as certification and quarantine personnel will find the information presented in this book useful.

29243.52 рублей

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Provides coverage of Motor Current Signature Analysis (MCSA) for cage induction motors This book is primarily for industrial engineers. It has 13 chapters and contains a unique data base of 50 industrial case histories on the application of MCSA to diagnose broken rotor bars or unacceptable levels of airgap eccentricity in cage induction motors with ratings from 127 kW (170 H.P.) up to 10,160 kW (13,620 H.P.). There are also unsuccessful case histories, which is another unique feature of the book. The case studies also illustrate the effects of mechanical load dynamics downstream of the motor on the interpretation of current signatures. A number of cases are presented where abnormal operation of the driven load was diagnosed. Chapter 13 presents a critical appraisal of MCSA including successes, failures and lessons learned via industrial case histories. The case histories are presented in a step by step format, with predictions and outcomes supported by current spectra and photographic evidence to confirm a correct or incorrect diagnosis The case histories are presented in detail so readers fully understand the diagnosis The authors have 108 years of combined experience in the installation, maintenance, repair, design, manufacture, operation and condition monitoring of SCIMs There are 10 questions at the end of chapters 1 to 12 and answers can be obtained via the publisher Current Signature Analysis for Condition Monitoring of Cage Induction Motors serves as a reference for professional engineers, head electricians and technicians working with induction motors. To obtain the solutions manual for this book, please send an email to [email protected] William T. Thomson is Director and Consultant with EM Diagnostics Ltd, in Scotland. Prof. Thomson received a BSc (Hons) in Electrical Engineering in 1973 and an MSc in 1977 from the University of Strathclyde. He has published 72 papers on condition monitoring of induction motors in a variety of engineering journals such as IEEE Transactions (USA), IEE Proceedings (UK), and also at numerous International IEEE and IEE conferences. He is a senior member of the IEEE, a fellow of the IEE (IET) in the UK and a Chartered Professional Engineer registered in the UK. Ian Culbert was a Rotating Machines Specialist at Iris Power Qualitrol since April 2002 until his very untimely death on 8th September, 2015. At this company he provided consulting services to customers, assisted in product development, trained sales and field service staff and reviewed stator winding partial discharge reports. He has co-authored two books on electrical machine insulation design, evaluation, aging, testing and repair and was principal author of a number of Electric Power Research Institute reports on motor repair. Ian was a Registered Professional Engineer in the Province of Ontario, Canada and a Senior Member of IEEE.

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