hena rahman and anil chandra toxicity of different root canal sealers an in vitro analysis

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Pablo Steinberg High-Throughput Screening Methods in Toxicity Testing

Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's «Toxicity Testing in the 21st Century: A Vision and Strategy» and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing is divided into five parts: General aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailed information about data generation, data analysis, and applications in risk assessment. The authors not only enumerate the advantages of each high-throughput method over comparable conventional methods, but also point out the high-throughput method's limitations and potential pitfalls. In addition, the authors describe current research efforts to make high-throughput toxicity screening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures and illustrations to help them understand and perform the latest high-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers who need to implement high-throughput screening methods for toxicity testing in their laboratories as well as for researchers who need to evaluate the data generated by these methods.

12835.53 рублей

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Nestor Cohenca Disinfection of Root Canal Systems. The Treatment of Apical Periodontitis

Clean root canal systems are essential for successful endodontic treatment. With contributions from leading endodontists from around the world, Dr. Nestor Cohenca here presents the etiology of endodontic disease caused by the endodontic biofilm and all therapies available to predictably disinfect the root canal system, thus increasing successful endodontic outcomes. Disinfection of Root Canal Systems: The Treatment of Apical Periodontitis is an evidence-based manual that describes root canal anatomy, the endodontic biofilm, and the role of disinfection before presenting the most up-to-date methods of irrigation and disinfection. Individual chapters are devoted to each method, such as positive pressure irrigation, apical negative pressure irrigation, sonic activation, photodynamic therapy, laser technology, and ozonization and electrochemical activation. Clinical photographs throughout show proper irrigation and disinfection techniques.

9298.12 рублей

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Henrik Holbech Statistical Analysis of Ecotoxicity Studies

A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book’s topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: • Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals • Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity • Includes an introduction to toxicity experiments and statistical analysis basics • Includes programs in R and excel • Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues • Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.

9075.63 рублей

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Martin Crespi Root Genomics and Soil Interactions

Fully integrated and comprehensive in its coverage, Root Genomics and Soil Interactions examines the use of genome-based technologies to understand root development and adaptability to biotic and abiotic stresses and changes in the soil environment. Written by an international team of experts in the field, this timely review highlights both model organisms and important agronomic crops. Coverage includes: novel areas unveiled by genomics research basic root biology and genomic approaches applied to analysis of root responses to the soil environment. Each chapter provides a succinct yet thorough review of research.

17110.15 рублей

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Howard Luke R. Analysis of Antioxidant-Rich Phytochemicals

To quantify antioxidants in natural sources, the application of chromatography techniques with different detectors followed by skillful sample preparation is necessary. Analysis of Antioxidant-Rich Phytochemicals is the first book that specifically covers and summarizes the details of sample preparation procedures and methods developed to identify and quantify various types of natural antioxidants in foods. Focusing on the principle of quantification methods for natural antioxidants, the book reviews and summarizes current methods used in the determination of antioxidant-rich phytochemicals in different sources. Chapter by chapter, the distinguished team of authors describes the various methods used for analysis of the different antioxidant-rich phytochemicals – phenolic acids; carotenoids; anthocyanins; ellagitannins, flavonols and flavones; catechins and procyanidins; flavanones; stilbenes; phytosterols; and tocopherols and tocotrienols. Going beyond extensive reviews of the scientific literature, the expert contributors call on their accumulated experience in sample extraction and analysis to outline procedures, identify potential problems in dealing with different samples, and offer trouble-shooting tips for the analysis. Analysis of Antioxidant-Rich Phytochemicals covers the important food applications and health-promoting functions of the major antioxidant phytochemicals, presents general analysis principles and procedures, and systematically reviews and summarizes the various analytical methods necessary for each type of natural antioxidant in different food sources.

17965.85 рублей

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John Clary J. The Toxicology of Methanol

The Toxicology of Methanol presents a single source of information and an understanding of the toxicity of methanol from animal data, potential environmental effects as well as human effects. The animal data, which goes to making up the majority of the data on the toxicity of methanol and the mechanism of action, is reviewed as it relates to the potential toxicity in humans.

10657.38 рублей

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Yuliang Zhao Toxicology of Nanomaterials

This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.

14248.49 рублей

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Daniel Arrigo J. Symmetry Analysis of Differential Equations. An Introduction

A self-contained introduction to the methods and techniques of symmetry analysis used to solve ODEs and PDEs Symmetry Analysis of Differential Equations: An Introduction presents an accessible approach to the uses of symmetry methods in solving both ordinary differential equations (ODEs) and partial differential equations (PDEs). Providing comprehensive coverage, the book fills a gap in the literature by discussing elementary symmetry concepts and invariance, including methods for reducing the complexity of ODEs and PDEs in an effort to solve the associated problems. Thoroughly class-tested, the author presents classical methods in a systematic, logical, and well-balanced manner. As the book progresses, the chapters graduate from elementary symmetries and the invariance of algebraic equations, to ODEs and PDEs, followed by coverage of the nonclassical method and compatibility. Symmetry Analysis of Differential Equations: An Introduction also features: Detailed, step-by-step examples to guide readers through the methods of symmetry analysis End-of-chapter exercises, varying from elementary to advanced, with select solutions to aid in the calculation of the presented algorithmic methods Symmetry Analysis of Differential Equations: An Introduction is an ideal textbook for upper-undergraduate and graduate-level courses in symmetry methods and applied mathematics. The book is also a useful reference for professionals in science, physics, and engineering, as well as anyone wishing to learn about the use of symmetry methods in solving differential equations.

6899.07 рублей

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Emanuela Corsini Molecular Immunotoxicology

The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.

14623.43 рублей

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Kerr Kathleen F. Design and Analysis of Experiments in the Health Sciences

An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health.

5052.53 рублей

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Andrei Bourchtein Counterexamples on Uniform Convergence. Sequences, Series, Functions, and Integrals

A comprehensive and thorough analysis of concepts and results on uniform convergence Counterexamples on Uniform Convergence: Sequences, Series, Functions, and Integrals presents counterexamples to false statements typically found within the study of mathematical analysis and calculus, all of which are related to uniform convergence. The book includes the convergence of sequences, series and families of functions, and proper and improper integrals depending on a parameter. The exposition is restricted to the main definitions and theorems in order to explore different versions (wrong and correct) of the fundamental concepts and results. The goal of the book is threefold. First, the authors provide a brief survey and discussion of principal results of the theory of uniform convergence in real analysis. Second, the book aims to help readers master the presented concepts and theorems, which are traditionally challenging and are sources of misunderstanding and confusion. Finally, this book illustrates how important mathematical tools such as counterexamples can be used in different situations. The features of the book include: An overview of important concepts and theorems on uniform convergence Well-organized coverage of the majority of the topics on uniform convergence studied in analysis courses An original approach to the analysis of important results on uniform convergence based\ on counterexamples Additional exercises at varying levels of complexity for each topic covered in the book A supplementary Instructor’s Solutions Manual containing complete solutions to all exercises, which is available via a companion website Counterexamples on Uniform Convergence: Sequences, Series, Functions, and Integrals is an appropriate reference and/or supplementary reading for upper-undergraduate and graduate-level courses in mathematical analysis and advanced calculus for students majoring in mathematics, engineering, and other sciences. The book is also a valuable resource for instructors teaching mathematical analysis and calculus. ANDREI BOURCHTEIN, PhD, is Professor in the Department of Mathematics at Pelotas State University in Brazil. The author of more than 100 referred articles and five books, his research interests include numerical analysis, computational fluid dynamics, numerical weather prediction, and real analysis. Dr. Andrei Bourchtein received his PhD in Mathematics and Physics from the Hydrometeorological Center of Russia. LUDMILA BOURCHTEIN, PhD, is Senior Research Scientist at the Institute of Physics and Mathematics at Pelotas State University in Brazil. The author of more than 80 referred articles and three books, her research interests include real and complex analysis, conformal mappings, and numerical analysis. Dr. Ludmila Bourchtein received her PhD in Mathematics from Saint Petersburg State University in Russia.

6370.45 рублей

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Pawlowsky-Glahn Vera Compositional Data Analysis. Theory and Applications

It is difficult to imagine that the statistical analysis of compositional data has been a major issue of concern for more than 100 years. It is even more difficult to realize that so many statisticians and users of statistics are unaware of the particular problems affecting compositional data, as well as their solutions. The issue of ``spurious correlation'', as the situation was phrased by Karl Pearson back in 1897, affects all data that measures parts of some whole, such as percentages, proportions, ppm and ppb. Such measurements are present in all fields of science, ranging from geology, biology, environmental sciences, forensic sciences, medicine and hydrology. This book presents the history and development of compositional data analysis along with Aitchison's log-ratio approach. Compositional Data Analysis describes the state of the art both in theoretical fields as well as applications in the different fields of science. Key Features: Reflects the state-of-the-art in compositional data analysis. Gives an overview of the historical development of compositional data analysis, as well as basic concepts and procedures. Looks at advances in algebra and calculus on the simplex. Presents applications in different fields of science, including, genomics, ecology, biology, geochemistry, planetology, chemistry and economics. Explores connections to correspondence analysis and the Dirichlet distribution. Presents a summary of three available software packages for compositional data analysis. Supported by an accompanying website featuring R code. Applied scientists working on compositional data analysis in any field of science, both in academia and professionals will benefit from this book, along with graduate students in any field of science working with compositional data.

9490.51 рублей

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Nicolas Bordenave Functional Foods and Beverages. In vitro Assessment of Nutritional, Sensory, and Safety Properties

A much-needed guide to in vitro food functionality evaluation principles, processes, and state-of-the-art modeling There are more than a few books devoted to the assessment of food functionality but, until now, there were no comprehensive guides focusing on the increasingly important subject of in vitro food evaluation. With contributions from the world’s foremost experts in the field, this book brings readers up to speed on the state-of-the-art in in vitro modeling, from its physiological bases to its conception, current uses, and future developments. Food functionality is a broad concept encompassing nutritional and health functionality, food safety and toxicology, as well as a broad range of visual and organoleptic properties of food. In vitro techniques bridge the gap between standard analytical techniques, including chemical and biochemical approaches and in vivo human testing, which remains the ultimate translational goal for evaluation of the functionality of food. Although it is a well- established field, in vitro food testing continues to evolve toward ever more accurate predictions of in vivo properties and outcomes. Both ethical and highly economical, these approaches allow for detailed mechanistic insights into food functionalities and, therefore, a better understanding of the interactions of food and human physiology. Reviews the core concepts of food functionality and functionality evaluation methodologies Provides an overview of the physiology of the gastrointestinal tract, including host-microbial interactions within it Delves into the physiology of sensory perception of food, taste and texture as they relate to in vitro modeling Explores the challenges of linking in vitro analysis of taste, aroma and flavor to their actual perception Addresses in vitro models of the digestion and absorption of macronutrients, micronutrients, and phytonutrients Describes in vitro evaluations of toxicants, allergens and other specific food hazards Functional Foods and Beverages is an indispensable working resource for food scientists as well as researchers working in government facilities dedicated to tracking food safety.

12961.94 рублей

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Hamid Laga 3D Shape Analysis. Fundamentals, Theory, and Applications

An in-depth description of the state-of-the-art of 3D shape analysis techniques and their applications This book discusses the different topics that come under the title of «3D shape analysis». It covers the theoretical foundations and the major solutions that have been presented in the literature. It also establishes links between solutions proposed by different communities that studied 3D shape, such as mathematics and statistics, medical imaging, computer vision, and computer graphics. The first part of 3D Shape Analysis: Fundamentals, Theory, and Applications provides a review of the background concepts such as methods for the acquisition and representation of 3D geometries, and the fundamentals of geometry and topology. It specifically covers stereo matching, structured light, and intrinsic vs. extrinsic properties of shape. Parts 2 and 3 present a range of mathematical and algorithmic tools (which are used for e.g., global descriptors, keypoint detectors, local feature descriptors, and algorithms) that are commonly used for the detection, registration, recognition, classification, and retrieval of 3D objects. Both also place strong emphasis on recent techniques motivated by the spread of commodity devices for 3D acquisition. Part 4 demonstrates the use of these techniques in a selection of 3D shape analysis applications. It covers 3D face recognition, object recognition in 3D scenes, and 3D shape retrieval. It also discusses examples of semantic applications and cross domain 3D retrieval, i.e. how to retrieve 3D models using various types of modalities, e.g. sketches and/or images. The book concludes with a summary of the main ideas and discussions of the future trends. 3D Shape Analysis: Fundamentals, Theory, and Applications is an excellent reference for graduate students, researchers, and professionals in different fields of mathematics, computer science, and engineering. It is also ideal for courses in computer vision and computer graphics, as well as for those seeking 3D industrial/commercial solutions.

12135.41 рублей

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Matthias Dehmer Applied Statistics for Network Biology. Methods in Systems Biology

The book introduces to the reader a number of cutting edge statistical methods which can e used for the analysis of genomic, proteomic and metabolomic data sets. In particular in the field of systems biology, researchers are trying to analyze as many data as possible in a given biological system (such as a cell or an organ). The appropriate statistical evaluation of these large scale data is critical for the correct interpretation and different experimental approaches require different approaches for the statistical analysis of these data. This book is written by biostatisticians and mathematicians but aimed as a valuable guide for the experimental researcher as well computational biologists who often lack an appropriate background in statistical analysis.

14094.81 рублей

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Raimo Pohjanvirta The AH Receptor in Biology and Toxicology

This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.

13298.39 рублей

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Bhattacharyya Lokesh Applications of Ion Chromatography in the Analysis of Pharmaceutical and Biological Products

This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing. In addition, an appendix section gives information on critical physical and chromatographic parameters related to IC and information on current manufacturers of IC systems, columns, and other components.

10657.38 рублей

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A comprehensive and thorough analysis of concepts and results on uniform convergence Counterexamples on Uniform Convergence: Sequences, Series, Functions, and Integrals presents counterexamples to false statements typically found within the study of mathematical analysis and calculus, all of which are related to uniform convergence. The book includes the convergence of sequences, series and families of functions, and proper and improper integrals depending on a parameter. The exposition is restricted to the main definitions and theorems in order to explore different versions (wrong and correct) of the fundamental concepts and results. The goal of the book is threefold. First, the authors provide a brief survey and discussion of principal results of the theory of uniform convergence in real analysis. Second, the book aims to help readers master the presented concepts and theorems, which are traditionally challenging and are sources of misunderstanding and confusion. Finally, this book illustrates how important mathematical tools such as counterexamples can be used in different situations. The features of the book include: An overview of important concepts and theorems on uniform convergence Well-organized coverage of the majority of the topics on uniform convergence studied in analysis courses An original approach to the analysis of important results on uniform convergence based\ on counterexamples Additional exercises at varying levels of complexity for each topic covered in the book A supplementary Instructor’s Solutions Manual containing complete solutions to all exercises, which is available via a companion website Counterexamples on Uniform Convergence: Sequences, Series, Functions, and Integrals is an appropriate reference and/or supplementary reading for upper-undergraduate and graduate-level courses in mathematical analysis and advanced calculus for students majoring in mathematics, engineering, and other sciences. The book is also a valuable resource for instructors teaching mathematical analysis and calculus. ANDREI BOURCHTEIN, PhD, is Professor in the Department of Mathematics at Pelotas State University in Brazil. The author of more than 100 referred articles and five books, his research interests include numerical analysis, computational fluid dynamics, numerical weather prediction, and real analysis. Dr. Andrei Bourchtein received his PhD in Mathematics and Physics from the Hydrometeorological Center of Russia. LUDMILA BOURCHTEIN, PhD, is Senior Research Scientist at the Institute of Physics and Mathematics at Pelotas State University in Brazil. The author of more than 80 referred articles and three books, her research interests include real and complex analysis, conformal mappings, and numerical analysis. Dr. Ludmila Bourchtein received her PhD in Mathematics from Saint Petersburg State University in Russia.

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